Evidence map›Paper›PMID 33857746›Full record

ArticleLeukemia research2021

Arsenic trioxide therapy predisposes to herpes zoster reactivation despite minimally myelosuppressive therapy.

Jacob L Glass, Andriy Derkach, Patrick Hilden, Amber King, Susan K Seo, Katya Ahr, Ashwin Kishtagari, Ross L Levine, Martin S Tallman, Dan Douer

Open access · greenAbstract read
In one paragraph

Article in Leukemia research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jacob L GlassDepartment of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, United States. Electronic address: glassj@mskcc.org.
Andriy DerkachDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, United States.
Patrick HildenDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, United States.
Amber KingDepartment of Pharmacy, Memorial Sloan Kettering Cancer Center, United States.
Susan K SeoDepartment of Medicine, Infectious Disease Service, Memorial Sloan Kettering Cancer Center, United States.
Katya AhrLewis Katz School of Medicine, Temple University, United States.
Ashwin KishtagariDepartment of Medicine, Mount Sinai St. Luke's West Hospital, United States.
Ross L LevineDepartment of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, United States.
Martin S TallmanDepartment of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, United States. Electronic address: tallmanm@mskcc.org.
Dan DouerDepartment of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, United States. Electronic address: douer_d@med.usc.edu.
Memorial Sloan Kettering Cancer Center · USTemple University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Lineage identification and targeted therapeutics in acute leukemiaK08CA230172 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI GLASS, JACOB LOWELL · 2019 to 2023
$1.4M
NCI NIH HHS K08 CA230172NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Acute Promyelocytic Leukemia (APL) is a unique subtype of acute myeloid leukemia that is highly responsive to minimally myelosuppressive therapy with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). We and others have observed a higher than expected incidence of herpes zoster reactivation in APL patients treated with ATO. Memorial Sloan Kettering Cancer Center (MSKCC) has been using ATO since 1997 in all relapsed APL patients, and more recently has included it in our front-line APL regimens. Here we present a retrospective analysis of the factors contributing to herpes zoster reactivation among APL patients.

Indexed as

Herpesvirus 3, HumanAntineoplastic AgentsArsenic TrioxideDisease SusceptibilityHerpes ZosterHumansImmunosuppressive AgentsLeukemia, Promyelocytic, AcuteRetrospective StudiesVirus ActivationAntineoplastic AgentsArsenic TrioxideImmunosuppressive AgentsAcute promyelocytic leukemiaArsenic trioxideHerpes zoster

Identifiers

PMID33857746
PMCPMC8187313
OpenAlexW3142176715

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.