Evidence map›Paper›PMID 33857575›Full record

ReviewProgress in cardiovascular diseases

Clinical and translational insights on premature ventricular contractions and PVC-induced cardiomyopathy.

Jose F Huizar, Alex Y Tan, Karoly Kaszala, Kenneth A Ellenbogen

Abstract readReview
In one paragraph

Review in Progress in cardiovascular diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Antiarrhythmic Treatment in Heart Failure.Current heart failure reports · 2024
    Review
  8. Frontiers in premature beats research: a bibliometric analysis.Frontiers in cardiovascular medicine · 2024
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Alterations of sarcoplasmic reticulum-mediated CaMolecular and cellular biochemistry · 2023
    Article
  14. Abnormal Conduction-Induced Cardiomyopathy: JACC Review Topic of the Week.Journal of the American College of Cardiology · 2023
    Review
  15. Article
  16. Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jose F HuizarPauley Heart Center, Virginia Commonwealth University, Richmond, VA, United States of America; Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, VA, United States of America. Electronic address: jfhuizar@vcuhealth.org.
Alex Y TanPauley Heart Center, Virginia Commonwealth University, Richmond, VA, United States of America; Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, VA, United States of America.
Karoly KaszalaPauley Heart Center, Virginia Commonwealth University, Richmond, VA, United States of America; Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, VA, United States of America.
Kenneth A EllenbogenPauley Heart Center, Virginia Commonwealth University, Richmond, VA, United States of America.

Funding

Mechanistic Insights of Premature Ventricular Contractions-induced CardiomyopathyR01HL139874 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI HUIZAR, JOSE FRANCISCO · 2018 to 2020
$2.0M
Prospective Assessment of Premature Ventricular Contractions Suppression in Cardiomyopathy(PAPS): A Pilot StudyR34HL138110 · NHLBI · RICHMOND INSTITUTE FOR VETERANS RESEARCH · PI DE MARCO, TERESA, ELLENBOGEN, KENNETH ALAN · 2017 to 2019
$601k
Mechanistic Insight of Premature Ventricular Contractions-induced CardiomyopathyR56HL133182 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI HUIZAR, JOSE FRANCISCO · 2016 to 2016
$507k
Neural Mechanisms of Premature Ventricular Contraction-Induced Cardiomyopathy Revealed by Targeted Neuromodulation of the Cardiac NeuraxisR01HL173183 · NHLBI · RICHMOND INSTITUTE FOR VETERANS RESEARCH · PI TAN, ALEX Y · 2025 to 2025
$473k
Validation of Premature Ventricular Contraction-induced Cardiomyopathy on a Swine ModelI01BX004861 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI Jose Francisco Huizar · 2020 to 2026
–
BLRD VA I01 BX004859BLRD VA I01 BX004861BLRD VA IS1 BX005574NHLBI NIH HHS R01 HL139874NHLBI NIH HHS R01 HL173183NHLBI NIH HHS R34 HL138110NHLBI NIH HHS R56 HL133182
6 · The paper itself

Abstract

The medical community's understanding of the consequences of premature ventricular contractions (PVCs) and PVC-induced cardiomyopathy has been derived mostly from observational and large population-based studies. Due to the difficulty of predicting the development of PVC-cardiomyopathy, the acute and chronic cardiac effects of PVCs and the mechanism of PVC-cardiomyopathy have been derived from pre-clinical studies with large animal models. Recently, these studies have described myocardial substrates that could potentially increase morbidity and mortality in patients with frequent PVCs and PVC-cardiomyopathy. In this paper, we provide an up-to-date comprehensive review of these pre-clinical and clinical studies.

Indexed as

CardiomyopathiesVentricular Premature ComplexesAction PotentialsAnimalsHeart Conduction SystemHeart RateHumansPrevalencePrognosisRisk FactorsTranslational Research, BiomedicalEccentric hypertrophyHeart rate irregularityLV dyssynchronyPremature atrial contractionPremature ventricular contraction

Identifiers

PMID33857575
PMCPMC9192164

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.