ArticleThe Annals of thoracic surgery2022
The Impact of Center Volume on Outcomes in Lung Transplantation.
Article in The Annals of thoracic surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Impact of lung allocation policy reforms on center volume redistribution and survival after lung transplantation.JHLT open · 2026Article
- Revised Deep Learning Semiparametric Regression for Testing and Estimating Treatment Effect Heterogeneity in Observational Studies: A Lung Transplant Case Study.bioRxiv : the preprint server for biology · 2026Article
- Time as a Therapeutic Ally: The Promise of Long-Term Solid Organ and Tissue Perfusion.Transplant international : official journal of the European Society for Organ Transplantation · 2026Review
- Liver transplant volume association with presence of heart and lung transplant programs: analysis of SRTR metrics.General thoracic and cardiovascular surgery · 2026Article
- Safety and early outcomes of nighttime lung transplantation with a surgical multidisciplinary team in a low-volume center.Journal of thoracic disease · 2025Article
- Lung Transplantation With Elevated Pulmonary Vascular Resistance: Insights From the United Network for Organ Sharing Database.Annals of thoracic surgery short reports · 2025Article
- Basiliximab induction immunosuppression and lung transplant outcomes: Propensity analysis in a multicenter cohort.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2025Article
- Lung transplant outcomes by surgeon practice and volume.JHLT open · 2025Article
- The role of coronary artery disease in lung transplantation: a propensity-matched analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Article
- Transplantation, bridging, and support technologies in pulmonary hypertension.The European respiratory journal · 2024Review
- Effects of case volume on short- and long-term outcomes following cadaveric lung transplantation in Japan.Journal of thoracic disease · 2024Article
- Limited cumulative experience with ex vivo lung perfusion is associated with inferior outcomes after lung transplantation.The Journal of thoracic and cardiovascular surgery · 2024Article
- Article
- Lung Transplantation Outcomes in Recipients Aged 70 Years or Older and the Impact of Center Volume.Journal of clinical medicine · 2023Article
- Impact of institutional case volume of solid organ transplantation on patient outcomes and implications for healthcare policy in Korea.Korean journal of transplantation · 2023Review
- Lungs From Donors ≥70 Years of Age for Transplantation-Do Long-Term Outcomes Justify Their Use?Transplant international : official journal of the European Society for Organ Transplantation · 2023Article
- Could global surgery overcome a decline in surgical cases?Annals of medicine and surgery (2012) · 2022Article
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Authors and funding
15 authors.
Funding
Abstract
backgroundStudies in lung transplantation have shown variable association between hospital volume and clinical outcomes. We aimed to identify the pattern of effect of hospital volume on individual patient survival after lung transplantation.
methodsWe performed a retrospective analysis using the United Network for Organ Sharing national thoracic organ transplantation database. Adult patients who underwent lung transplantation between January 2013 and December 2017 were included. The association between mean annual center volume and 1-year overall survival was examined using restricted cubic splines in a random effects multivariable Cox model. The volume threshold for optimal 1-year overall survival was subsequently approximated by the maximum likelihood approach using segmented linear splines in the same model.
resultsThe study included 10,007 patients at 71 transplant centers. Median annual center volume was 22 cases (interquartile range, 10.6 to 38). A center volume threshold was identified at 33 cases per year (95% confidence interval, 28 to 37). Higher center volume, to 33 cases per year, was associated with better 1-year survival (hazard ratio 0.989, 95% confidence interval, 0.980 to 0.999 every additional case). Further increase in center volume above 33 cases per year showed no additional benefit (hazard ratio 1.000, 95% confidence interval, 0.996 to 1.003 every additional case). Twenty-three centers (32.4%) reached the volume threshold of 33 cases per year.
conclusionsOne-year survival after lung transplantation improved with increasing center volume to as many as 33 cases per year. Low volume centers below the 33 cases per year threshold had large variations in their outcomes and had a higher risk of performing poorly, although many of them maintained good performance.
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