ArticleTrends in psychiatry and psychotherapy2022
Childhood trauma is associated with onset of symptoms, functioning and cognition in patients with schizophrenia.
Article in Trends in psychiatry and psychotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- The Impact of Childhood Maltreatment on the Bipolar Disorder Course and Prognosis: A Systematic Review and Meta-Analysis.Clinical psychology & psychotherapyPooled it
- Differential associations of childhood trauma subtypes with clinical symptoms, cognitive function, suicidal intent, and age at onset in Chinese patients with chronic schizophrenia.European archives of psychiatry and clinical neuroscience · 2026Article
- Dynamic frontoparietal flexibility and cognitive dysfunction in schizophrenia: disentangling the roles of symptom burden and childhood trauma.Psychological medicine · 2026Article
- Role of childhood trauma in interoception and alexithymia in schizophrenia.Journal of psychiatric research · 2026Article
- Associations between childhood trauma, cognitive function, and clinical symptoms in first-episode schizophrenia.Frontiers in psychiatry · 2026Article
- Effects of Childhood Trauma on Remembering the Past and Imagining the Future in Schizophrenia.PsyCh journal · 2025Article
- Linking childhood trauma to the psychopathology of schizophrenia: the role of oxytocin.Schizophrenia (Heidelberg, Germany) · 2024Article
- Association of childhood trauma with cognitive domains in adult patients with mental disorders and in non-clinical populations: a systematic review.Frontiers in psychology · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionChildhood trauma (CT) is known to be a vulnerability factor for schizophrenia, but the specific impacts of different trauma subtypes on the prognosis of these patients remains unclear.
objectiveTo assess the relationships between the occurrence of overall CT and its subtypes with factors with known prognostic impact on schizophrenia, such as age at onset of symptoms, global functioning, and cognitive impairment in a sample of Brazilian patients.
methodsOne hundred and five stable patients diagnosed with schizophrenia according to DSM-5 criteria were evaluated using the Independent Living Skills Survey (ILSS; self-report global functioning), Schizophrenia Cognition Rating Scale (SCoRS; subjective cognitive impairment), and Childhood Trauma Questionnaire scales (CTQ; perceived overall CT, emotional neglect, physical neglect, physical abuse, and emotional and sexual abuse). Statistical analysis was performed with multivariate linear regression.
resultsAfter controlling for educational level and age, subjective cognitive impairment was directly correlated with overall perceived CT occurrence, emotional abuse, and sexual abuse. Self-report global functioning was inversely correlated with perceived overall CT occurrence, emotional abuse, and sexual abuse. Emotional abuse and physical abuse were also inversely correlated with age at onset of symptoms.
conclusionsCT can be related to more severe prognoses in schizophrenia, impacting on early onset of symptoms, lower global functioning, and greater cognitive impairment. Subtypes of trauma can be associated with different prognostic risks.
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