ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021
Viral Sequencing to Investigate Sources of SARS-CoV-2 Infection in US Healthcare Personnel.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- The prevalence of probable mental health disorders among hospital healthcare workers during COVID-19: A systematic review and meta-analysis.Journal of affective disorders · 2023Pooled it
- Risk factors for acquisition of SARS-CoV-2 Omicron variant among a prospective cohort of French Healthcare Workers: impact of hybrid immunity.Scientific reports · 2026Article
- SARS-CoV-2 surveillance and vaccine effectiveness among dental healthcare workers during the omicron surge.Scientific reports · 2026Article
- Genomic and Phylogenetic Dissection of SARS-CoV-2 Transmission Networks in Healthcare Workers.International journal of microbiology · 2026Article
- Association between social activities and risk of COVID-19 in a cohort of healthcare personnel.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Occupational risk of COVID-19 related hospital admission in Skåne, Sweden: A register-based cohort study.PloS one · 2025Article
- Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 in a Rural Community Hospital during Omicron Predominance.Microorganisms · 2024Article
- SARS-CoV-2 seropositivity among healthcare professionals in a rural state.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024Article
- COVID-19 outbreak and genomic investigation in an inpatient behavioral health unit.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024Article
- Associations between an international COVID-19 job exposure matrix and SARS-CoV-2 infection among 2 million workers in Denmark.Scandinavian journal of work, environment & health · 2023Article
- SARS-CoV-2 Outbreak Investigation Using Contact Tracing and Whole-Genome Sequencing in an Ontario Tertiary Care Hospital.Microbiology spectrum · 2023Article
- The Relative Contributions of Occupational and Community Risk Factors for COVID-19 among Hospital Workers: The HOP-COVID Cohort Study.Journal of clinical medicine · 2023Article
- Key predictors of psychological distress and wellbeing in Australian frontline healthcare workers during COVID-19 (Omicron wave).Frontiers in psychology · 2023Article
- Considerations for de-escalating universal masking in healthcare centers.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023Review
- SARS-CoV-2 Genomic Diversity in Households Highlights the Challenges of Sequence-Based Transmission Inference.mSphere · 2022Article
- Understanding Early Pandemic Severe Acute Respiratory Syndrome Coronavirus 2 Transmission in a Medical Center by Incorporating Public Sequencing Databases to Mitigate Bias.The Journal of infectious diseases · 2022Article
- Genomic Investigation to Identify Sources of Severe Acute Respiratory Syndrome Coronavirus 2 Infection Among Healthcare Personnel in an Acute Care Hospital.Open forum infectious diseases · 2022Article
- Identifying Contact Risks for SARS-CoV-2 Transmission to Healthcare Workers during Outbreak on COVID-19 Ward.Emerging infectious diseases · 2022Article
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Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHealthcare personnel (HCP) are at increased risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We posit that current infection control guidelines generally protect HCP from SARS-CoV-2 infection in a healthcare setting.
methodsIn this retrospective case series, we used viral genomics to investigate the likely source of SARS-CoV-2 infection in HCP at a major academic medical institution in the Upper Midwest of the United States between 25 March and 27 December 2020. We obtained limited epidemiological data through informal interviews and review of the electronic health record and combined this information with healthcare-associated viral sequences and viral sequences collected in the broader community to infer the most likely source of infection in HCP.
resultsWe investigated SARS-CoV-2 infection clusters involving 95 HCP and 137 possible patient contact sequences. The majority of HCP infections could not be linked to a patient or coworker (55 of 95 [57.9%]) and were genetically similar to viruses circulating concurrently in the community. We found that 10.5% of HCP infections (10 of 95) could be traced to a coworker. Strikingly, only 4.2% (4 of 95) could be traced to a patient source.
conclusionsInfections among HCP add further strain to the healthcare system and put patients, HCP, and communities at risk. We found no evidence for healthcare-associated transmission in the majority of HCP infections evaluated. Although we cannot rule out the possibility of cryptic healthcare-associated transmission, it appears that HCP most commonly become infected with SARS-CoV-2 via community exposure. This emphasizes the ongoing importance of mask wearing, physical distancing, robust testing programs, and rapid distribution of vaccines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.