ArticlePLoS genetics2021
Two transcriptionally distinct pathways drive female development in a reptile with both genetic and temperature dependent sex determination.
Article in PLoS genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Trpv4 links environmental temperature to testicular differentiation in hermaphroditic ricefield eel.eLife · 2026Article
- Genotype-by-environment interactive effects and conflict solving during gonadal sex differentiation of pejerrey Odontesthes bonariensis, a fish with dual genotypic/environmental sex determination.Biology of sex differences · 2025Article
- Article
- Single-nucleus transcriptional and chromatin accessible profiles reveal critical cell types and molecular architecture underlying chicken sex determination.Journal of advanced research · 2025Article
- Article
- Genome Assembly of a Living Fossil, the Atlantic Horseshoe Crab Limulus polyphemus, Reveals Lineage-Specific Whole-Genome Duplications, Transposable Element-Based Centromeres, and a ZW Sex Chromosome System.Molecular biology and evolution · 2025Article
- Pro-cumulin addition in a biphasic in vitro oocyte maturation system modulates human oocyte and cumulus cell transcriptomes.Molecular human reproduction · 2025Article
- A near telomere-to-telomere phased genome assembly and annotation for the Australian central bearded dragon Pogona vitticeps.GigaScience · 2025Article
- In vitro organ culture protocol for intact urogenital systems supporting gonadal differentiation.PloS one · 2025Article
- Understanding the genetic sex-determining mechanism in Hyla eximia treefrog inferred from H-Y antigen.PloS one · 2024Article
- New chromosome-scale genomes provide insights into marine adaptations of sea snakes (Hydrophis: Elapidae).BMC biology · 2023Article
- Gene expression of male pathway genes sox9 and amh during early sex differentiation in a reptile departs from the classical amniote model.BMC genomics · 2023Article
- Genome-wide association study reveals genomic loci of sex differentiation and gonadal development inFrontiers in genetics · 2023Article
- Article
- Computational modelling of plasticity-led evolution.Biophysical reviews · 2022Review
- Developmental dynamics of sex reprogramming by high incubation temperatures in a dragon lizard.BMC genomics · 2022Article
- TruncatedScience advances · 2022Article
- Sex-specific splicing of Z- and W-borneProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Epigenetic Regulation and Environmental Sex Determination in Cichlid Fishes.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2021Review
- PAXFrontiers in cell and developmental biology · 2021Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
How temperature determines sex remains unknown. A recent hypothesis proposes that conserved cellular mechanisms (calcium and redox; 'CaRe' status) sense temperature and identify genes and regulatory pathways likely to be involved in driving sexual development. We take advantage of the unique sex determining system of the model organism, Pogona vitticeps, to assess predictions of this hypothesis. P. vitticeps has ZZ male: ZW female sex chromosomes whose influence can be overridden in genetic males by high temperatures, causing male-to-female sex reversal. We compare a developmental transcriptome series of ZWf females and temperature sex reversed ZZf females. We demonstrate that early developmental cascades differ dramatically between genetically driven and thermally driven females, later converging to produce a common outcome (ovaries). We show that genes proposed as regulators of thermosensitive sex determination play a role in temperature sex reversal. Our study greatly advances the search for the mechanisms by which temperature determines sex.
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