Evidence map›Paper›PMID 33856917›Full record

ArticleCirculation research2021

Is the Failing Heart Starved of Mitochondrial Calcium?

Joanne F Garbincius, John W Elrod

Abstract readEditorialComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Mitochondrial CaJACC. Basic to translational science · 2024
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Enhanced NCLX-dependent mitochondrial CaJournal of molecular and cellular cardiology · 2022
    Article
  12. Review
  13. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Joanne F GarbinciusCenter for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
John W ElrodCenter for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.

Funding

Small and large animal surgery, physiology and histologyP01HL134608 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI Raj Kishore · 2017 to 2026
$21.0M
Targeting Pathways Involved in Cardiac Injury for Novel Repair StrategiesP01HL147841 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI KOCH, WALTER J. · 2020 to 2024
$11.4M
Integrative Cardiovascular PathophysiologyT32HL091804 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2008 to 2024
$4.5M
Molecular composition of the mitochondrial calcium uniporter and cardiac pathophysiologyR01HL142271 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI ELROD, JOHN WILLIAM, HAJNOCZKY, GYORGY · 2018 to 2021
$3.0M
Novel Molecular Mechanisms of Programmed NecrosisR01HL136954 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2017 to 2020
$1.6M
Molecular modulation of the mitochondrial Na+/Ca2+ exchanger as a novel therapeutic target for heart failure.F32HL151146 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI GARBINCIUS, JOANNE FRANCES · 2020 to 2021
$134k
NHLBI NIH HHS F32 HL151146NHLBI NIH HHS P01 HL134608NHLBI NIH HHS P01 HL147841NHLBI NIH HHS R01 HL136954NHLBI NIH HHS R01 HL142271NHLBI NIH HHS T32 HL091804
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CalciumMitochondriaHeartCalciumanimal modelscalciumcardiac myocyteEditorialsheart failuremitochondria

Identifiers

PMID33856917
PMCPMC8475748

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.