Evidence map›Paper›PMID 33856807›Full record

ArticleJournal of the American Chemical Society2021

Glutamate Mediates Proton-Coupled Electron Transfer Between Tyrosines 730 and 731 in

Clorice R Reinhardt, Elvira R Sayfutyarova, Jiayun Zhong, Sharon Hammes-Schiffer

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Low-barrier hydrogen bond powers long-range radical transfer in the metal-free ribonucleotide reductase.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Allosteric gating of radical transport in ribonucleotide reductase.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Conformationally gated multisite proton-coupled electron transfer in the ribonucleotide reductaseProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. FeSBCP analogue from cyanobacteria: insights from in vitro and in silico studies.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. 2.6-Å resolution cryo-EM structure of a class Ia ribonucleotide reductase trapped with mechanism-based inhibitor NProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Article
  11. Surface-Accelerated String Method for Locating Minimum Free Energy Paths.Journal of chemical theory and computation · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
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  17. Journal of the American Chemical Society · 2022
    Article
  18. Kinetic model for reversible radical transfer in ribonucleotide reductase.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Clorice R ReinhardtDepartment of Molecular Biophysics & Biochemistry, Yale University, 266 Whitney Avenue, New Haven, Connecticut 06520, United States.ORCID 0000-0002-6083-4950
Elvira R SayfutyarovaDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520, United States.ORCID 0000-0001-8403-5013
Jiayun ZhongDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520, United States.
Sharon Hammes-SchifferDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520, United States.ORCID 0000-0002-3782-6995
Yale University · USWhitney Museum of American Art · US

Funding

Predoc Training at the Interface Chemistry and BiologyT32GM067543 · NIGMS · YALE UNIVERSITY · PI CRAWFORD, JASON MICHAEL · 2003 to 2022
$7.4M
Simulation of Proton and Hydride Transfer in EnzymesR37GM056207 · NIGMS · YALE UNIVERSITY · PI HAMMES-SCHIFFER, SHARON · 2011 to 2020
$3.2M
SIMULATION OF PROTON AND HYDRIDE TRANSFER IN ENZYMESR01GM056207 · NIGMS · UNIVERSITY OF NOTRE DAME · PI HAMMES-SCHIFFER, SHARON · 1998 to 2010
$2.7M
Coupled Protons and Electrons in Biological SystemsR35GM139449 · NIGMS · YALE UNIVERSITY · PI HAMMES-SCHIFFER, SHARON · 2021 to 2025
$2.1M
NIGMS NIH HHS R01 GM056207NIGMS NIH HHS R35 GM139449NIGMS NIH HHS R37 GM056207NIGMS NIH HHS T32 GM067543
6 · The paper itself

Abstract

Ribonucleotide reductase (RNR) is an essential enzyme in DNA synthesis for all living organisms. It reduces ribonucleotides to the corresponding deoxyribonucleotides by a reversible radical transfer mechanism. The active form of

Indexed as

Electron TransportEscherichia coliGlutamic AcidHydrogen BondingMolecular Dynamics SimulationProtein Structure, QuaternaryProtonsQuantum TheoryRibonucleotide ReductasesStatic ElectricityThermodynamicsTyrosineGlutamic AcidProtonsRibonucleotide ReductasesTyrosine

Identifiers

PMID33856807
PMCPMC8500205
OpenAlexW3154844660

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.