Evidence map›Paper›PMID 33856739›Full record

ArticleACR open rheumatology2021

Gout, Rheumatoid Arthritis, and the Risk of Death Related to Coronavirus Disease 2019: An Analysis of the UK Biobank.

Ruth K Topless, Amanda Phipps-Green, Megan Leask, Nicola Dalbeth, Lisa K Stamp, Philip C Robinson, Tony R Merriman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACR open rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 5 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 5 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Ruth K ToplessUniversity of Otago, Dunedin, New Zealand.
Amanda Phipps-GreenUniversity of Otago, Dunedin, New Zealand.
Megan LeaskUniversity of Otago, Dunedin, New Zealand, and University of Alabama at Birmingham.
Nicola DalbethThe University of Auckland, Auckland, New Zealand.ORCID https://orcid.org/0000-0003-4632-4476
Lisa K StampUniversity of Otago, Christchurch, Christchurch, New Zealand.ORCID https://orcid.org/0000-0003-0138-2912
Philip C RobinsonUniversity of Queensland, Brisbane, Queensland, Australia.ORCID https://orcid.org/0000-0002-3156-3418
Tony R MerrimanUniversity of Otago, Dunedin, New Zealand, and University of Alabama at Birmingham.ORCID https://orcid.org/0000-0003-0844-8726
University of Otago · NZUniversity of Alabama at Birmingham · USThe University of Queensland · AUUniversity of Auckland · NZ

Funding

Health Research Council of New Zealand 19/206Medical Research Council MC_PC_17228Medical Research Council MC_QA137853
6 · The paper itself

Abstract

objectivesThe objectives for this study were to assess whether gout and/or rheumatoid arthritis (RA) are risk factors for coronavirus disease 2019 (COVID-19) diagnosis and to assess whether gout and/or RA are risk factors for death from COVID-19.

methodsWe used data from the UK Biobank. Multivariable-adjusted logistic regression was employed in the following analyses: analysis A, to test for association between gout and/or RA and COVID-19 diagnosis (n = 473,139); analysis B, to test for association between gout and/or RA and death from COVID-19 in a case-control cohort of people who died of or survived COVID-19 (n = 2059); analysis C, to test for association between gout and/or RA and death from COVID-19 in the entire UK Biobank cohort (n = 473,139).

resultsRA, but not gout, was associated with COVID-19 diagnosis in analysis A. Neither RA nor gout was associated with risk of death in the group diagnosed with COVID-19 in analysis B. However, RA was associated with risk of death related to COVID-19 by using the UK Biobank cohort in analysis C, independent of comorbidities and other measured risk factors (odds ratio [OR] 1.9; 95% confidence interval CI 1.2-3.0). Gout was not associated with death related to COVID-19 in the same UK Biobank analysis (OR 1.2; 95% CI 0.8-1.7).

conclusionRA is a risk factor for death from COVID-19 by using the UK Biobank cohort. These findings require replication in larger data sets that also allow for inclusion of a wider range of factors.

Identifiers

PMID33856739
PMCPMC8126763
OpenAlexW3155960323

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.