ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2021
Risk factors for ischemic stroke in children with tuberculous meningitis.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 22 citations in OpenAlex.
- Basal Ganglia Ischemic Stroke as Sentinel Sign for Pediatric Tuberculous Meningitis in an Immunocompetent Child: A Case Report.Pediatric reports · 2026Article
- Understanding ischemia in children with tuberculous meningitis (iThemba): a protocol paper.BMC pediatrics · 2026Article
- Brain Imaging and Whole Blood Targeted Transcriptomic Analyses to Characterize Cerebral Infarctions in Children With Tuberculous Meningitis.The Journal of infectious diseases · 2025Article
- Focal Cerebral Arteriopathy and Stroke Secondary to Tuberculous Meningitis.Annals of the Child Neurology Society · 2025Article
- Tuberculous meningitis-related ischemic stroke: A retrospective study from a tertiary care hospital.Journal of clinical tuberculosis and other mycobacterial diseases · 2025Article
- Prevention of stroke and cognitive decline in pediatric population in resource-limited settings.Frontiers in stroke · 2024Review
- Analysis of risk factors for acute cerebral infarction in patients with intracranial tuberculosis.Frontiers in neurology · 2024Article
- Global trends and regional differences in disease burden of stroke among children: a trend analysis based on the global burden of disease study 2019.BMC public health · 2023Article
- Advances in the Diagnosis and Treatment of Pediatric Arterial Ischemic Stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Risk factors of poor developmental outcome in children with tuberculous meningitis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Pulmonary Tuberculosis-Related Ischemic Stroke: A Retrospective Case Control Study.Journal of inflammation research · 2022Article
- The Impact of Hyponatremia on the Severity of Childhood Tuberculous Meningitis.Frontiers in neurology · 2021Article
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Authors and funding
4 authors at 1 institution in 2 countries.
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Abstract
purposeCerebrovascular complications are commonly observed in children with tuberculous meningitis. We aimed to determine which clinical factors were associated with stroke at admission in children with tuberculous meningitis and, in children stroke-free at admission, which factors were associated with development of stroke on treatment.
methodsWe analysed a cohort of 474 children diagnosed with 'definite' and 'probable' tuberculous meningitis, with prospectively collected data, at Tygerberg Hospital, Cape Town, South Africa from 1985 to 2005. We considered either hemiparesis or radiological arterial ischemic infarction as evidence of stroke.
resultsAt admission, 339 (71.5%) children presented with stroke. Features associated with stroke at admission included age <3 years (odds ratio (OR) 3.70; 95% confidence interval (CI): 2.44-5.63; p < 0.01), convulsions (OR: 2.25; 95% CI: 1.46-3.45; p < 0.01) and hydrocephalus (OR: 1.63; 95% CI: 1.05-2.53; p = 0.03). In the group of children without stroke at admission (n = 135), 33 (24.4%) developed stroke by 1 month. Similar factors predicted stroke and included age <3 years (OR: 2.60; 95% CI: 1.17-5.80; p = 0.02), convulsions (OR: 2.25; 95% CI: 1.46-3.45; p < 0.01), CSF cell count <10 or >500/L (OR: 3.12; 95% CI: 1.03-9.43; p = 0.04) and hydrocephalus (OR: 2.99; 95% CI: 1.30-6.89; p = 0.01).
conclusionA large proportion of children with tuberculous meningitis present with stroke at admission. Of those with no evidence of stroke at admission, a quarter develop stroke by 1 month, suggesting that there could be a brief window in which to give preventive therapy.
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