ReviewThe western journal of emergency medicine2021
Evidence-Based Heatstroke Management in the Emergency Department.
Review in The western journal of emergency medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 62 citations in OpenAlex.
- A clinical activation protocol improves response time to urgent/emergent neurosurgical care in children with brain tumors and intracranial hemorrhage.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- [DGIIN action algorithm: management of heat-related illnesses in clinical acute care and emergency medicine].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026Article
- Mechanisms and Intervention Strategies for Heat Stroke-Associated Myocardial Dysfunction: A Narrative Review.The western journal of emergency medicine · 2026Review
- 12-Year Case Series of Patients with Heat Illness from an Urban Hospital System in the American Southwest.The western journal of emergency medicine · 2026Article
- Perfect storm: a scoping review of interventions and preparedness strategies at the intersections of climate change, migrant worker health and health systems.BMJ public health · 2026Article
- Heatstroke knowledge and predictors among Hajj health volunteers in Saudi Arabia: a cross-sectional study.PeerJ · 2026Article
- Gut microbiota modulation in the prevention and treatment of heat stroke.Frontiers in immunology · 2026Review
- Development and validation of the predictive scoring system for 90-day mortality in critical ill patients with exertional heatstroke.Renal failure · 2025Article
- Emergency Department Management of Acute Heatstroke: A Retrospective Analysis from Phoenix, Arizona.The western journal of emergency medicine · 2025Observational
- Heat-related illnesses: a scoping review of health system strategies, emergency responses and interventions in heat-prone areas.BMC public health · 2025Article
- Article
- Liver fatty acid-binding protein point-of-care testing detects heat-induced organ damage: a pilot study in Japanese male self-defense force personnel.Scientific reports · 2025Article
- Impact of hyper- and hypothermia on cellular and whole-body physiology.Journal of intensive care · 2025Review
- Long-Term Impact of HEAT Educational Intervention in the Emergency Department in Karachi, Pakistan.Annals of global health · 2025Article
- Heat stroke dysfunctions: from pathophysiology to prediction.Frontiers in physiology · 2025Review
- Article
- Article
- Validity of an ICD-10 Coding Algorithm for Acute Heat Illness in the Emergency Department: A Retrospective Cohort Study.International journal of environmental research and public health · 2024Article
- [Pathophysiology and management of heat illness].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Review
- Timely accessibility to healthcare resources and heatwave-related mortality in 7 major cities of South Korea: a two-stage approach with principal component analysis.The Lancet regional health. Western Pacific · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionClimate change is causing an increase in the frequency and intensity of extreme heat events, which disproportionately impact the health of vulnerable populations. Heatstroke, the most serious heat-related illness, is a medical emergency that causes multiorgan failure and death without intervention. Rapid recognition and aggressive early treatment are essential to reduce morbidity and mortality. The objective of this study was to evaluate current standards of care for the emergent management of heatstroke and propose an evidence-based algorithm to expedite care.
methodsWe systematically searched PubMed, Embase, and key journals, and reviewed bibliographies. Original research articles, including case studies, were selected if they specifically addressed the recognition and management of heatstroke in any prehospital, emergency department (ED), or intensive care unit population. Reviewers evaluated study quality and abstracted information regarding demographics, scenario, management, and outcome.
resultsIn total, 63 articles met full inclusion criteria after full-text review and were included for analysis. Three key themes identified during the qualitative review process included recognition, rapid cooling, and supportive care. Rapid recognition and expedited external or internal cooling methods coupled with multidisciplinary management were associated with improved outcomes. Delays in care are associated with adverse outcomes. We found no current scalable ED alert process to expedite early goal-directed therapies.
conclusionGiven the increased risk of exposure to heat waves and the time-sensitivity of the condition, EDs and healthcare systems should adopt processes for rapid recognition and management of heatstroke. This study proposes an evidence-based prehospital and ED heat alert pathway to improve early diagnosis and resource mobilization. We also provide an evidence-based treatment pathway to facilitate efficient patient cooling. It is hoped that this protocol will improve care and help healthcare systems adapt to changing environmental conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.