ArticleAnnals of intensive care2021
Monitoring skin blood flow to rapidly identify alterations in tissue perfusion during fluid removal using continuous veno-venous hemofiltration in patients with circulatory shock.
Article in Annals of intensive care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Prognostic value of capillary refill time in adult patients: a systematic review with meta-analysis.Critical care (London, England) · 2023Pooled it
- Time-dependent microvascular and analgesic responses to cold compression in healthy adults: identifying the optimal cooling duration for recovery.European journal of applied physiology · 2026Trial
- Ultrafiltration in the critically ill patient: a framework for personalized care.Critical care (London, England) · 2026Review
- Biomedical optical imaging of acne pathology: from single-modality methods to multimodal integration.Frontiers in medicine · 2026Review
- Laser Doppler mapping of lower limb skin perfusion before and 5 h after exercise in warm conditions.Frontiers in physiology · 2026Article
- Multimodal assessment of peripheral perfusion in critically ill patients: a pilot study.Annals of intensive care · 2025Article
- Skin injury: Associations with variables related to perfusion and pressure.Anaesthesia and intensive care · 2024Article
- The nuts and bolts of fluid de-escalation.Intensive care medicine · 2023Article
- Bone mesenchymal stem cell extracellular vesicles delivered miR let-7-5p alleviate endothelial glycocalyx degradation and leakage via targeting ABL2.Cell communication and signaling : CCS · 2023Article
- Serum vascular endothelial growth factor affects tissue fluid accumulation and is associated with deteriorating tissue perfusion and oxygenation in severe sepsis: a prospective observational study.European journal of medical research · 2023Observational
- Fluid removal tolerance during the de-escalation phase: is preload unresponsiveness the best guiding candidate?Critical care (London, England) · 2023Article
- Transfusion increased skin blood flow when initially low in volume-resuscitated patients without acute bleeding.Frontiers in medicine · 2023Article
- A plea for personalization of the hemodynamic management of septic shock.Critical care (London, England) · 2022Review
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundContinuous veno-venous hemofiltration (CVVH) can be used to reduce fluid overload and tissue edema, but excessive fluid removal may impair tissue perfusion. Skin blood flow (SBF) alters rapidly in shock, so its measurement may be useful to help monitor tissue perfusion.
methodsIn a prospective, observational study in a 35-bed department of intensive care, all patients with shock who required fluid removal with CVVH were considered for inclusion. SBF was measured on the index finger using skin laser Doppler (Periflux 5000, Perimed, Järfälla, Sweden) for 3 min at baseline (before starting fluid removal, T0), and 1, 3 and 6 h after starting fluid removal. The same fluid removal rate was maintained throughout the study period. Patients were grouped according to absence (Group A) or presence (Group B) of altered tissue perfusion, defined as a 10% increase in blood lactate from T0 to T6 with the T6 lactate ≥ 1.5 mmol/l. Receiver operating characteristic curves were constructed and areas under the curve (AUROC) calculated to identify variables predictive of altered tissue perfusion. Data are reported as medians [25th-75th percentiles].
resultsWe studied 42 patients (31 septic shock, 11 cardiogenic shock); median SOFA score at inclusion was 9 [8-12]. At T0, there were no significant differences in hemodynamic variables, norepinephrine dose, lactate concentration, ScvO
conclusionBaseline SBF and its early reduction after initiation of fluid removal using CVVH can predict worsened tissue perfusion, reflected by an increase in blood lactate levels.
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