Evidence map›Paper›PMID 33855641›Full record

ReviewWorld journal of microbiology & biotechnology2021

Construction of recombinant Escherichia coli for production of L-phenylalanine-derived compounds.

Liwen Liu, Xiaozhen Liu, Qianqian Ma, Qiang Li, Pengfei Gu

Abstract readReview
PubMed Publisher
In one paragraph

Review in World journal of microbiology & biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Prospective bacterial and fungal sources of hyaluronic acid: A review.Computational and structural biotechnology journal · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Liwen LiuSchool of Biological Science and Technology, University of Jinan, Jinan, 250022, People's Republic of China.
Xiaozhen LiuSchool of Biological Science and Technology, University of Jinan, Jinan, 250022, People's Republic of China.
Qianqian MaSchool of Biological Science and Technology, University of Jinan, Jinan, 250022, People's Republic of China.
Qiang LiSchool of Biological Science and Technology, University of Jinan, Jinan, 250022, People's Republic of China.
Pengfei GuSchool of Biological Science and Technology, University of Jinan, Jinan, 250022, People's Republic of China. bio_gupf@ujn.edu.cn.ORCID http://orcid.org/0000-0001-9275-9636
University of Jinan · CN

Funding

National Natural Science Foundation of China 31600066Rizhao science and technology innovation project 2020CXZX1206Science and Technology Program of University of Jinan XKY2028
6 · The paper itself

Abstract

L-phenylalanine is an important amino acid that is widely used in the fields of food flavors and pharmaceuticals. Apart from L-phenylalanine itself, various commercially valuable chemical compounds can also be generated via the L-phenylalanine biosynthesis pathway. Compared with direct extraction from plants or synthesis by chemical reaction, microbial production of L-phenylalanine -derived compounds can overcome the drawbacks of environmental pollution, low yield, and mixtures of stereoisomeric products. Accordingly, increasing intracellular levels of precursors, deregulating feedback inhibition and transcription repression, engineering global regulators and other effective strategies have been implemented to produce different L-phenylalanine -derived compounds in the excellent chassis host Escherichia coli. Finally, this review highlights principal strategies for improving the production of L-phenylalanine and/or its derivatives in E. coli, and discusses the future outlook for further enhancing the titer and yields of these compounds.

Indexed as

Biosynthetic PathwaysEscherichia coliEscherichia coli ProteinsGene Expression Regulation, BacterialHydrocarbons, AromaticIndustrial MicrobiologyMetabolic EngineeringPhenylalanineEscherichia coli ProteinsHydrocarbons, AromaticPhenylalanineEscherichia coliL-phenylalanine derived compoundMetabolic engineeringRegulatory factor

Identifiers

PMID33855641
OpenAlexW3153834667

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.