Evidence map›Paper›PMID 33855252›Full record

ArticleJournal of the Endocrine Society2021

Lumbar Scoliosis in Postmenopausal Women Increases with Age but is not Associated with Osteoporosis.

Janet Rubin, Rebecca J Cleveland, Alexander Padovano, David Hu, Maya Styner, James Sanders

Open access · goldAbstract read
In one paragraph

Article in Journal of the Endocrine Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Janet RubinDivision of Endocrinology and Metabolism, Department of Medicine, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27514, USA.ORCID https://orcid.org/0000-0003-3534-8667
Rebecca J ClevelandThurston Arthritis Research Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA.ORCID https://orcid.org/0000-0003-0022-1025
Alexander PadovanoDepartment of Orthopaedics, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27514, USA.ORCID https://orcid.org/0000-0001-9176-3844
David HuThurston Arthritis Research Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Maya StynerDivision of Endocrinology and Metabolism, Department of Medicine, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27514, USA.ORCID https://orcid.org/0000-0001-9790-8645
James SandersDepartment of Orthopaedics, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27514, USA.
University of North Carolina at Chapel Hill · US

Funding

Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6M
UNC Core Center for Clinical ResearchP30AR072580 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEIGH Fleming CALLAHAN, Amanda E Nelson · 2019 to 2026
$6.1M
ELECTRIC FIELD ATTENUATION OF OSTEOCLAST FORMATIONR01AR042360 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUBIN, JANET E · 1993 to 2013
$2.8M
Role of force regulated nuclear structure in expression of osteogenesisR01AR075803 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUBIN, JANET E · 2020 to 2024
$2.4M
Marrow Adipose Compartment Physiology in Caloric Restriction and AgingR01AR073264 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STYNER, MAYA SHALEV · 2019 to 2023
$1.7M
NCATS NIH HHS UL1 TR002489NIAMS NIH HHS P30 AR072580NIAMS NIH HHS R01 AR042360NIAMS NIH HHS R01 AR073264NIAMS NIH HHS R01 AR075803
6 · The paper itself

Abstract

contextThe contribution of lumbar scoliosis to osteoporosis is unknown.

objectiveThis work aimed to determine the prevalence and relationship of lumbar scoliosis to osteoporosis in aging women.

methodsA cross-sectional analysis used dual-energy x-ray absorptiometry (DXA) scans of randomly selected groups of postmenopausal women (64-68, 74-78, and 84-88 years; N = 300 each) in a university teaching hospital from 2014 to 2019. Lumbar Cobb angle was tested for an association to femoral neck (FN), total hip (TH), and spine T score, age, weight, and ethnicity. Logistic regression tested an association between scoliosis (Cobb angle > 10°) and osteoporosis (T score ≤ -2.5). Available sequential DXA scans (N = 51) were analyzed for changes in Cobb angle using a linear mixed model of these longitudinal data.

resultsOsteoporosis and Cobb angle both increased with age: from 22% and 4.4 (SD = 7.8) respectively in 64- to 68-year-olds to 32.9% and to 9.7 (SD = 9.2) in women age 84 to 88 years. The prevalence of clinically significant scoliosis rose from 11.5% in the youngest group, to 27.3% and 39.4% in the age 74 to 78 and 84 to 88 cohorts, respectively. Cobb angle increased 0.7° per year of follow-up. After adjusting for covariates, there was no significant association between T scores at any site (TH, FN, or spine) and Cobb angle.

conclusionBased on screening DXAs, the incidence and degree of lumbar scoliosis increases significantly in women between age 65 and 85 years. There was no association between the incidence of lumbar scoliosis and FN bone density.

Indexed as

agingbone densityCobb angle

Identifiers

PMID33855252
PMCPMC8023369
OpenAlexW3130271956

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.