Evidence map›Paper›PMID 33855226›Full record

Observational studyEndocrinology, diabetes & metabolism2021

Differences in quality of life between genders in acromegaly.

Daniel Ballesteros-Herrera, Paulina Briseño-Hernández, Rodrigo Pérez-Esparza, Lesly A Portocarrero-Ortiz

Open access · goldAbstract readComparative StudyObservational Study
In one paragraph

Observational study in Endocrinology, diabetes & metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Anxiety, depression and acromegaly: a systematic review.Journal of endocrinological investigation · 2025
    Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. The acromegaly patient experience: burden of treatment and quality of life.The Journal of clinical endocrinology and metabolism · 2026
    Review
  7. Review
  8. Article
  9. Article
  10. Skin manifestations and submacroscopical features of acromegaly: A case-control study using dermoscopy and high-frequency ultrasound.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023
    Observational
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Daniel Ballesteros-HerreraDepartment of Neurosurgery, Instituto Nacional de Neurología y Neurocirugía, MVS, Mexico City, Mexico.ORCID https://orcid.org/0000-0003-3837-8765
Paulina Briseño-HernándezUniversidad Nacional Autónoma de México, Mexico City, Mexico.
Rodrigo Pérez-EsparzaDepartment of Neuropsychiatry, INNN, Mexico City, Mexico.
Lesly A Portocarrero-OrtizUniversidad Nacional Autónoma de México, Mexico City, Mexico.ORCID https://orcid.org/0000-0003-2051-4861
Universidad Nacional Autónoma de México · MXInstituto Nacional de Neurología y Neurocirugía · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To study the impact of secondary mental disorders in patients affected with acromegaly and correlate them with quality of life (QoL) and disease status. Design: An observational transversal descriptive and comparative study that evaluates QoL's impact due to secondary mental disorders in affected Mexicans with acromegaly using AcroQoL and SF-36 instruments. Correlation of the results with the disease's biochemical status was performed. According to Beck's scales, anxiety and depression analyses evaluate QoL's impact, and its gender variability is described. Results: Eighty-five patients with diagnoses of acromegaly were included. The mean age was 43.18 years, 47 being women (55.29%). The mean age at diagnosis was 37.95 years, with no difference between men and women. AcroQoL and SF-36 global and sub-domain scores differed significantly between men and women, the latter having lower global and individual sub-domain scores. The mean score of QoL, according to AcroQoL, is 59.40. In women, the mean values are less (55.13) than men (64.68), Conclusion: Correlations between female gender, depression/anxiety scores and QoL require further validation. There is much to be routinely done to improve secondary psychopathology in patients affected by this disease. The need for mental status screening at diagnosis should be emphasized to identify secondary mental illnesses to improve QoL with its treatment.

Indexed as

Quality of LifeAcromegalyAdultAnxietyDepressionFemaleHumansMaleMental DisordersSex Factorsacromegalyanxietydepressiongenderquality of life

Identifiers

PMID33855226
PMCPMC8029512
OpenAlexW3127008365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.