Evidence map›Paper›PMID 33855210›Full record

ArticleEndocrinology, diabetes & metabolism2021

RHAPSODY, Biomarkers and Novel Clinical Trial design in type 2 diabetes (T2D) and prediabetes.

Rachel Adams, Nicole Daly, Elizabeth Robertson, Giuseppe N Giordano

Abstract read
In one paragraph

Article in Endocrinology, diabetes & metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rachel AdamsJanssen, High Wycombe, Bucks, UK.ORCID https://orcid.org/0000-0003-0455-6447
Nicole DalyJanssen, High Wycombe, Bucks, UK.
Elizabeth RobertsonDiabetes UK Wells Lawrence House, London, UK.
Giuseppe N GiordanoDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, LUDC, Lund University, Skåne University Hospital, Malmö, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Developing a novel therapeutic product for the treatment of type 2 diabetes (T2D) is a long, resource-intensive process. Novel biomarkers could potentially aid clinical trial design by shortening clinical trials or enabling better prediction of at-risk populations and/or disease progression. Novel clinical trial designs could lead to reduced costs of development and less burden to patients, due to shorter trial duration, and/or less burdensome assessments.

Indexed as

BiomarkersClinical Trials as TopicResearch DesignCohort StudiesCost of IllnessCost SavingsDiabetes Mellitus, Type 2Disease ProgressionHumansMonitoring, PhysiologicPatient Reported Outcome MeasuresPrediabetic StateTime FactorsBiomarkersbiomarkersdisease progressionnovel clinical trial designprediabetestype 2 diabetes mellitus

Identifiers

PMID33855210
PMCPMC8029523

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.