Evidence map›Paper›PMID 33854951›Full record

ArticleToxicology reports2021

Acute oral toxicity of a novel functional drink based on

Geovanna Paladines-Santacruz, Andrea Orellana-Manzano, Glenda Sarmiento, Glenda Pilozo, Elsy Iñiga, Fausto Zaruma-Torres, Johana Ortíz-Ulloa, María Quijano-Avilés, Davide Di Grumo, Silvia Orellana-Manzano and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Guayusa (Molecules (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Geovanna Paladines-SantacruzESPOL Polytechnic University, Escuela Superior Politécnica del Litoral, ESPOL, Laboratorio para investigaciones biomédicas, Facultad de Ciencias de la vida (FCV), Campus Gustavo Galindo Km. 30.5 Vía Perimetral, P.O. Box 09-01-5863, Guayaquil, Ecuador.
Andrea Orellana-ManzanoESPOL Polytechnic University, Escuela Superior Politécnica del Litoral, ESPOL, Laboratorio para investigaciones biomédicas, Facultad de Ciencias de la vida (FCV), Campus Gustavo Galindo Km. 30.5 Vía Perimetral, P.O. Box 09-01-5863, Guayaquil, Ecuador.
Glenda SarmientoFacultad de Ciencias Químicas, Universidad de Guayaquil, Cdla. Universitaria "Salvador Allende", Malecón del Salado entre Av. Delta y Av. Kennedy, 090514, Guayaquil, Ecuador.
Glenda PilozoFacultad de Ciencias Químicas, Universidad de Guayaquil, Cdla. Universitaria "Salvador Allende", Malecón del Salado entre Av. Delta y Av. Kennedy, 090514, Guayaquil, Ecuador.
Elsy IñigaFacultad de Ciencias Químicas, Universidad de Guayaquil, Cdla. Universitaria "Salvador Allende", Malecón del Salado entre Av. Delta y Av. Kennedy, 090514, Guayaquil, Ecuador.
Fausto Zaruma-TorresLaboratorio de Proteínas y Farmacología, Universidad de Cuenca, Av. 12 de abril y Av. Loja, 010203, Cuenca, Ecuador.
Johana Ortíz-UlloaDepartamento de Biociencias. Grupo "Alimentación, Nutrición y Salud", Facultad de Ciencias Químicas, Universidad de Cuenca, Av. 12 de abril y Av. Loja, 010203, Cuenca, Ecuador.
María Quijano-AvilésESPOL Polytechnic University, Escuela Superior Politécnica del Litoral, ESPOL, Centro de Investigaciones Biotecnológicas del Ecuador (CIBE), Campus Gustavo Galindo Km. 30.5 Vía Perimetral, P.O. Box 09-01-5863, Guayaquil, Ecuador.
Davide Di GrumoSchool of Dentistry, University of Specialties Espiritu Santo, Samborondón, Ecuador.
Silvia Orellana-ManzanoSchool of Dentistry, University of Specialties Espiritu Santo, Samborondón, Ecuador.
María Del Carmen VillacrésFacultad de Ciencias Químicas, Universidad de Guayaquil, Cdla. Universitaria "Salvador Allende", Malecón del Salado entre Av. Delta y Av. Kennedy, 090514, Guayaquil, Ecuador.
Patricia ManzanoESPOL Polytechnic University, Escuela Superior Politécnica del Litoral, ESPOL, Centro de Investigaciones Biotecnológicas del Ecuador (CIBE), Campus Gustavo Galindo Km. 30.5 Vía Perimetral, P.O. Box 09-01-5863, Guayaquil, Ecuador.
Wim Vanden BergheUniversity of Antwerp, PPES, Epigenetic Signaling Lab, Faculty Biomedical Sciences, Prinsstraat 13, 2000, Wilrijk, Antwerp, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel functional drink with nutraceutical properties was formulated from the aqueous extracts of

Indexed as

Acute oral toxicityANOVA, One-way analysis of varianceAOT, Acute oral toxicityb.w., body weightCocoa huskFunctional drinkGHS, Globally Harmonized Classification SystemIlex guayusaINSPI, National Institute of Public Health Research of EcuadorLD50Median, lethal doseMCCH, Maquita Cushunchic FundationMiceOECD, Organization for Economic Cooperation and DevelopmentROW, Relative organ weightSD, Standard deviationVernonanthura patens

Identifiers

PMID33854951
PMCPMC8027533

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.