Evidence map›Paper›PMID 33854901›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Nanostructured Dense Collagen-Polyester Composite Hydrogels as Amphiphilic Platforms for Drug Delivery.

Xiaolin Wang, Olivier Ronsin, Basile Gravez, Nicolette Farman, Tristan Baumberger, Frédéric Jaisser, Thibaud Coradin, Christophe Hélary

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaolin WangSchool of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine Macau University of Science and Technology Taipa Macao 999078 China.
Olivier RonsinSorbonne Université CNRS Institut des NanoSciences de Paris INSP Paris F-75005 France.
Basile GravezINSERM Centre de Recherche des Cordeliers Sorbonne Université Université de Paris Paris F-75005 France.
Nicolette FarmanINSERM Centre de Recherche des Cordeliers Sorbonne Université Université de Paris Paris F-75005 France.
Tristan BaumbergerSorbonne Université CNRS Institut des NanoSciences de Paris INSP Paris F-75005 France.
Frédéric JaisserINSERM Centre de Recherche des Cordeliers Sorbonne Université Université de Paris Paris F-75005 France.
Thibaud CoradinSorbonne Université CNRS, UMR 7574, Laboratoire de Chimie de la Matière Condensée de Paris Paris F-75005 France.
Christophe HélarySorbonne Université CNRS, UMR 7574, Laboratoire de Chimie de la Matière Condensée de Paris Paris F-75005 France.ORCID 0000-0001-9312-7278

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Associating collagen with biodegradable hydrophobic polyesters constitutes a promising method for the design of medicated biomaterials. Current collagen-polyester composite hydrogels consisting of pre-formed polymeric particles encapsulated within a low concentrated collagen hydrogel suffer from poor physical properties and low drug loading. Herein, an amphiphilic composite platform associating dense collagen hydrogels and up to 50 wt% polyesters with different hydrophobicity and chain length is developed. An original method of fabrication is disclosed based on in situ nanoprecipitation of polyesters impregnated in a pre-formed 3D dense collagen network. Composites made of poly(lactic-

Indexed as

CollagenDrug Delivery SystemsHydrogelsIn Vitro TechniquesNanostructuresPolyestersSpironolactoneSurface-Active AgentsCollagenHydrogelsPolyestersSpironolactoneSurface-Active Agentscollagencompositesdense hydrogelsdrug delivery systemin situ nanoprecipitationpolyesters

Identifiers

PMID33854901
PMCPMC8025010

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.