Evidence map›Paper›PMID 33854810›Full record

ArticleJournal of gastric cancer2021

Pancreatic Fistula after D1+/D2 Radical Gastrectomy according to the Updated International Study Group of Pancreatic Surgery Criteria: Risk Factors and Clinical Consequences. Experience of Surgeons with High Caseloads in a Single Surgical Center in Eastern Europe.

Alexandru Martiniuc, Traian Dumitrascu, Mihnea Ionescu, Stefan Tudor, Monica Lacatus, Vlad Herlea, Catalin Vasilescu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastric cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Alexandru MartiniucDepartment of General Surgery, Fundeni Clinical Institute, Bucharest, Romania.ORCID https://orcid.org/0000-0002-9811-2478
Traian DumitrascuDepartment of General Surgery, Fundeni Clinical Institute, Bucharest, Romania.ORCID https://orcid.org/0000-0002-5343-7180
Mihnea IonescuDepartment of General Surgery, Fundeni Clinical Institute, Bucharest, Romania.ORCID https://orcid.org/0000-0003-4063-3585
Stefan TudorDepartment of General Surgery, Fundeni Clinical Institute, Bucharest, Romania.ORCID https://orcid.org/0000-0003-2933-2060
Monica LacatusDepartment of General Surgery, Fundeni Clinical Institute, Bucharest, Romania.ORCID https://orcid.org/0000-0002-5192-3396
Vlad HerleaDepartment of Pathology, Fundeni Clinical Institute, Bucharest, Romania.ORCID https://orcid.org/0000-0002-0125-7815
Catalin VasilescuDepartment of General Surgery, Fundeni Clinical Institute, Bucharest, Romania.ORCID https://orcid.org/0000-0003-0194-8779
Carol Davila University of Medicine and Pharmacy · ROInstitutul Clinic Fundeni · ROTitu Maiorescu University · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIncidence, risk factors, and clinical consequences of pancreatic fistula (POPF) after D1+/D2 radical gastrectomy have not been well investigated in Western patients, particularly those from Eastern Europe. MATERIALS AND

methodsA total of 358 D1+/D2 radical gastrectomies were performed by surgeons with high caseloads in a single surgical center from 2002 to 2017. A retrospective analysis of data that were prospectively gathered in an electronic database was performed. POPF was defined and graded according to the International Study Group for Pancreatic Surgery (ISGPS) criteria. Uni- and multivariate analyses were performed to identify potential predictors of POPF. Additionally, the impact of POPF on early complications and long-term outcomes were investigated.

resultsPOPF was observed in 20 patients (5.6%), according to the updated ISGPS grading system. Cardiovascular comorbidities emerged as the single independent predictor of POPF formation (risk ratio, 3.051; 95% confidence interval, 1.161-8.019; P=0.024). POPF occurrence was associated with statistically significant increased rates of postoperative hemorrhage requiring re-laparotomy (P=0.029), anastomotic leak (P=0.002), 90-day mortality (P=0.036), and prolonged hospital stay (P<0.001). The long-term survival of patients with gastric adenocarcinoma was not affected by POPF (P=0.661).

conclusionsIn this large series of Eastern European patients, the clinically relevant rate of POPF after D1+/D2 radical gastrectomy was low. The presence of co-existing cardiovascular disease favored the occurrence of POPF and was associated with an increased risk of postoperative bleeding, anastomotic leak, 90-day mortality, and prolonged hospital stay. POPF was not found to affect the long-term survival of patients with gastric adenocarcinoma.

Indexed as

ComplicationsGastric cancerPancreatic fistulaRadical gastrectomySurvival

Identifiers

PMID33854810
PMCPMC8020004
OpenAlexW3136659761

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.