ArticleTherapeutic advances in infectious disease
Efficacy and safety of vancomycin loading doses in critically ill patients with methicillin-resistant
Article in Therapeutic advances in infectious disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Sodium Alginate Microneedles Loaded with Vancomycin for Skin Infections.Journal of functional biomaterials · 2024Article
- Characterizing Day 1 Area Under the Curve Following Vancomycin Loading Dose Administration in Adult Hospitalized Patients Using Non-Trapezoidal Linear Pharmacokinetic Equations: A Retrospective Observational Study.Infectious diseases and therapy · 2024Article
- Impact of Limiting Vancomycin Loading Doses in Patients With Methicillin-resistantHospital pharmacy · 2024Article
- Impact of Vancomycin Loading Doses and Dose Escalation on Glomerular Function and Kidney Injury Biomarkers in a Translational Rat Model.Antimicrobial agents and chemotherapy · 2023Article
- Association of vancomycin-induced acute kidney injury with trough versus AUC monitoring in patients receiving extended durations of therapy.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023Article
- A Systematic Review on Clinical Safety and Efficacy of Vancomycin Loading Dose in Critically Ill Patients.Antibiotics (Basel, Switzerland) · 2022Review
- Vancomycin therapeutic monitoring by measured trough concentration versus Bayesian-derived area under the curve in critically ill patients with cancer.Pharmacology research & perspectives · 2022Article
- Vancomycin Loading Doses and Nephrotoxicity on Medicine Teaching Services.International journal of general medicine · 2022Article
- Ceftriaxone as an Alternative Therapy for the Treatment of Methicillin-SusceptibleCase reports in infectious diseases · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile vancomycin loading doses may facilitate earlier pharmacokinetic-pharmacodynamic target attainment, the impact of loading doses on clinical outcomes remains understudied. Critically ill patients are at highest risk of morbidity and mortality from methicillin resistant
methodsFour hundred and forty-nine critically ill patients with MRSA cultures isolated from blood or respiratory specimens were eligible for the study. Cohorts were established by receipt of a loading dose (⩾20 mg/kg actual body weight) or not. The primary outcome was clinical failure, a composite outcome of death within 30 days of first MRSA culture, blood cultures positive ⩾7 days, white blood cell count up to 5 days from vancomycin initiation, temperature up to 5 days from vancomycin initiation, or substitution (or addition) of another MRSA agent.
resultsThere was no difference in the percentage of patients experiencing clinical failure between the loading dose and no loading dose groups (74.8%
conclusionUse of vancomycin loading doses was not associated with improved clinical outcomes in critically ill patients with MRSA infection.
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