ArticleJournal of dental sciences2021
Efficacy of different calcium silicate materials as pulp-capping agents: Randomized clinical trial.
Article in Journal of dental sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Efficacy of theracal as pulp capping material in permanent dentition: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Effectiveness of calcium hydroxide compared to hydraulic calcium silicate cements for direct pulp capping in managing deep caries in vital permanent teeth: A systematic review and meta-analysis.International endodontic journal · 2025Pooled it
- Comparison of bioactive material failure rates in vital pulp treatment of permanent matured teeth - a systematic review and network meta-analysis.Scientific reports · 2024Pooled it
- Comparative efficacy of materials used in patients undergoing pulpotomy or direct pulp capping in carious teeth: A systematic review and meta-analysis.Clinical and experimental dental research · 2023Pooled it
- Clinical and radiographic evaluation of Er: YAG laser-assisted direct pulp capping in permanent teeth with carious exposure.Lasers in medical science · 2025Trial
- Clinical outcomes of selective removal to soft dentin versus firm dentin for deep caries lesions: a randomized controlled trial up to 5 years.Clinical oral investigations · 2024Trial
- [Evaluation of bioceramic putty repairmen iRoot and mineral trioxide aggregate in mature permanent teeth pulpotomy].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2022Trial
- Biological effects of a premixed calcium silicate pulp-capping material containing dimethyl sulphoxide as a vehicle: In vitro and in vivo study.European journal of oral sciences · 2026Article
- Clinical Outcomes of Immediate and Delayed Composite Restorations After Pulp Capping with Biodentine: A Systematic Literature Review.Journal of functional biomaterials · 2026Review
- Comparative Efficacy of Four Different Types of Medicaments for Pulpotomy of Primary Molars: A Clinical and Radiographic Study.International journal of clinical pediatric dentistry · 2026Article
- Effects of sodium hypochlorite and chlorhexidine on microhardness and solubility of mineral trioxide aggregate and bioceramic putty.Journal of conservative dentistry and endodontics · 2026Article
- Dose-dependent effects of Metformin on proliferation and odontogenic differentiation of dental pulp stem cells.BMC oral health · 2026Article
- Therapy and material choices in pulp exposure among public dentists in Norway.Acta odontologica Scandinavica · 2026Article
- Clinical and Radiographic Outcomes of Vital Pulp Therapy Using Resin-Modified Versus Conventional Calcium Silicate-Based Materials: A Systematic Review and Meta-Analysis.Journal of functional biomaterials · 2026Review
- Macrophage-Marker Response and Exploratory Hepatorenal Safety of a Tricalcium Silicate-Biogenic Calcium Carbonate (International journal of dentistry · 2026Article
- Decision-ready evidence for vital pulp therapy: a network meta-analysis of bioactive materials in mature permanent teeth.Frontiers in dental medicine · 2026Review
- TheraCal LC versus Mineral Trioxide Aggregate for full pulpotomy in cariously exposed mature permanent molars with symptomatic irreversible pulpitis: a randomized clinical trial.Biomaterial investigations in dentistry · 2026Article
- In vitro comparison of fracture strength of maxillary incisors with the simulated external root resorption cavities repaired with BioMTA or Biodentine.Journal of dental sciences · 2025Article
- Vital pulp therapies in permanent teeth: what, when, where, who, why and how?British dental journal · 2025Review
- Effectiveness of mineral trioxide aggregate and its modifications in inducing dentin bridge formation during pulp capping: A systematic review.Journal of conservative dentistry and endodontics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background/purposeCalcium hydroxide-based materials were the gold standard in vital pulp therapies for decades' despite of several shortcomings. However, calcium silicates have been discussed as an alternative to overcome these drawbacks. It was aimed to investigate the in-vivo effectiveness of different calcium silicates based materials in pulp capping in this study. MATERIALS AND
methodsA parallel-design, randomized controlled trial with 213 patients who has deep dentin caries, vital pulps and without spontaneous pain or history of swelling was designed. 525 M teeth were randomized, blinded and allocated to one of the five groups for pulp capping treatment (n = 105). All teeth were followed up clinically and radiographically (after 1st, 6th, 12th and 36th months) by blinded investigators. The clinical and radiographic success, and the effect of the pulp exposure to the success rate analyzed with Wald chi-square and Z tests.
resultsClinical and radiographic success of MTA+ (86.3%, 85.4%) and Biodentine (79.4%, 80.1%) were found the highest. Although results of Theracal LC group (72.1%, 73.6%) were better than Dycal group (69.4%, 70.2%), the difference was nonsignificant (p > 0.05). Only in light-cured groups, (TheraCal LC & LC Calcihyd) pulpal exposure size effected the success of the materials (p < 0.05). MTA+ and Biodentine resulted better scores, when compared with TheraCal LC in large pulpal exposures (p < 0.05).
conclusionAfter 36-month follow-up, both MTA+ and Biodentine were found to be the appropriate material for direct pulp capping in permanent teeth. The filler ingredient of the Theracal-LC eases the usage of calcium silicates but decreases the success rate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.