Evidence map›Paper›PMID 33854530›Full record

ReviewFrontiers in genetics2021

Deciphering Myostatin's Regulatory, Metabolic, and Developmental Influence in Skeletal Diseases.

Catherine L Omosule, Charlotte L Phillips

Abstract readReview
In one paragraph

Review in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
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  6. Exercise-myokine relationships in osteoarthritis.Journal of translational medicine · 2026
    Review
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  8. Article
  9. Article
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  14. Exerkines and osteoarthritis.Frontiers in physiology · 2023
    Review
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  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Catherine L OmosuleDepartment of Biochemistry, University of Missouri, Columbia, MO, United States.
Charlotte L PhillipsDepartment of Biochemistry, University of Missouri, Columbia, MO, United States.

Funding

Maternal Anti-myostatin (GDF8) Therapy to Enhance Offspring Musculoskeletal Health in Mouse Models of Osteogenesis ImperfectaR21AR077813 · NIAMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI PHILLIPS, CHARLOTTE L · 2020 to 2021
$368k
NIAMS NIH HHS R21 AR077813
6 · The paper itself

Abstract

Current research findings in humans and other mammalian and non-mammalian species support the potent regulatory role of myostatin in the morphology and function of muscle as well as cellular differentiation and metabolism, with real-life implications in agricultural meat production and human disease. Myostatin null mice (

Indexed as

diabetesDuchenne muscular dystrophymyostatinosteoblastosteoclastosteocyteosteogenesis imperfectaosteoporosis

Identifiers

PMID33854530
PMCPMC8039523

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.