Evidence map›Paper›PMID 33854440›Full record

ArticleFrontiers in physiology2021

Effects of Allicin on Late Sodium Current Caused by ΔKPQ-SCN5A Mutation in HEK293 Cells.

Yating Chen, Yun Huang, Jing Bai, Chuanbin Liu, Shanshan Ma, Jiaxin Li, Xu Lu, Zihao Fu, Lihua Fang, Yang Li and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Yating ChenDepartment of Cardiology, Fujian Provincial Hospital, Provincial Clinical Medicine College of Fujian Medical University, Fuzhou, China.
Yun HuangDepartment of Gerontology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jing BaiMedical School of Chinese People's Liberation Army (PLA), Beijing, China.
Chuanbin LiuMedical School of Chinese People's Liberation Army (PLA), Beijing, China.
Shanshan MaDepartment of Cardiology, The Sixth Medical Center, Chinese PLA General Hospital, Beijing, China.
Jiaxin LiDepartment of Cardiology, The Sixth Medical Center, Chinese PLA General Hospital, Beijing, China.
Xu LuMedical School of Chinese People's Liberation Army (PLA), Beijing, China.
Zihao FuMedical School of Chinese People's Liberation Army (PLA), Beijing, China.
Lihua FangDepartment of Cardiology, Fujian Provincial Hospital, Provincial Clinical Medicine College of Fujian Medical University, Fuzhou, China.
Yang LiDepartment of Cardiology, The Sixth Medical Center, Chinese PLA General Hospital, Beijing, China.
Jiancheng ZhangDepartment of Cardiology, Fujian Provincial Hospital, Provincial Clinical Medicine College of Fujian Medical University, Fuzhou, China.
Chinese People's Liberation Army · CNChinese PLA General Hospital · CNFujian Provincial Hospital · CNHuazhong University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe aim was to study the effect of Allitridum (Allicin) on the heterologous expression of the late sodium current on the ΔKPQ-SCN5A mutations in HEK293 cells, with a view to screening new drugs for the treatment of long QT syndrome type 3 (LQT3). METHODS AND

resultsThe ΔKPQ-SCN5A plasmid was transiently transferred into HEK293 cells by liposome technology and administered by extracellular perfusion, and the sodium current was recorded by whole-cell patch-clamp technology. Application of Allicin 30 μM reduced the late sodium current (

conclusionAllicin reduced the late sodium current of ΔKPQ-SCN5A, whose mechanism may be related to the increase of channel steady-state inactivation (SSI) and intermediate-state inactivation (ISI) by the drug, thus reducing the window current.

Indexed as

AllitridumHEK293 cellslate sodium currentLQT3ΔKPQ-SCN5A mutation

Identifiers

PMID33854440
PMCPMC8039306
OpenAlexW3141448288

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.