ArticleNature protocols2021
Human fetal whole-body postmortem microfocus computed tomographic imaging.
Article in Nature protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Clinical performance and microstructural assessment of hemodialysis catheters for children on maintenance dialysis.Pediatric nephrology (Berlin, Germany) · 2026Article
- Implementation of pediatric and fetal postmortem imaging into clinical practice: a multi-society statement from the ESPR, SPR, SLARP, AOSPR, WFPI, and IAFR.Pediatric radiology · 2026Review
- Differentiating ante-mortem from post-mortem findings on fetal and pediatric post-mortem imaging.Pediatric radiology · 2026Review
- Fetal and neonatal postmortem magnetic resonance imaging: indications protocols.Pediatric radiology · 2026Review
- Timing of Secondary Palate Fusion in Human Embryos and Fetuses.Birth defects research · 2026Article
- Miscarriage Tissue Research: Still in Its Infancy.Life (Basel, Switzerland) · 2026Review
- Mapping the anatomical and transcriptional landscape of early human fetal ovary development.Scientific reports · 2025Article
- Development of A Micro-CT Scanner with Dual-Energy Option and Endovascular Contrast Agent Administration Protocol for Fetal and Neonatal Virtual Autopsy.Journal of imaging · 2024Article
- Body weight-based iodinated contrast immersion timing for human fetal postmortem microfocus computed tomography.BJR open · 2024Article
- An integrated single-cell analysis of human adrenal cortex development.JCI insight · 2023Article
- Post-mortem perinatal imaging: what is the evidence?The British journal of radiology · 2023Review
- Microfocus computed tomography for fetal postmortem imaging: an overview.Pediatric radiology · 2023Article
- Comparison of postmortem whole-body contrast-enhanced microfocus computed tomography and high-field magnetic resonance imaging of human fetuses.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2022Article
- Micro-CT yields high image quality in human fetal post-mortem imaging despite maceration.BMC medical imaging · 2021Article
- A pragmatic evidence-based approach to post-mortem perinatal imaging.Insights into imaging · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Perinatal autopsy is the standard method for investigating fetal death; however, it requires dissection of the fetus. Human fetal microfocus computed tomography (micro-CT) provides a generally more acceptable and less invasive imaging alternative for bereaved parents to determine the cause of early pregnancy loss compared with conventional autopsy techniques. In this protocol, we describe the four main stages required to image fetuses using micro-CT. Preparation of the fetus includes staining with the contrast agent potassium triiodide and takes 3-19 d, depending on the size of the fetus and the time taken to obtain consent for the procedure. Setup for imaging requires appropriate positioning of the fetus and takes 1 h. The actual imaging takes, on average, 2 h 40 min and involves initial test scans followed by high-definition diagnostic scans. Postimaging, 3 d are required to postprocess the fetus, including removal of the stain, and also to undertake artifact recognition and data transfer. This procedure produces high-resolution isotropic datasets, allowing for radio-pathological interpretations to be made and long-term digital archiving for re-review and data sharing, where required. The protocol can be undertaken following appropriate training, which includes both the use of micro-CT techniques and handling of postmortem tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.