ArticleNature2021
Structural basis of long-range to short-range synaptic transition in NHEJ.
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In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.
0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
101 citing papers in PubMed, 156 citations in OpenAlex.
- MPP8 Facilitates DNA DSB Repair via NHEJ to Promote Chemoresistance of TNBC Independent of Methyl-H3K9 Binding.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Core NHEJ Factors Maintain Synapsis Across Diverse DNA End Structures.bioRxiv : the preprint server for biology · 2026Article
- End processing in NHEJ by Polymerase λ and PNKP is coordinated during short-range synapsis.Nature communications · 2026Article
- DNA-PK driven nucleosome unwrapping enables NHEJ in chromatin.Nature communications · 2026Article
- Youthfulness of marrow AdipoqBone research · 2026Article
- Ku70-SAP domain has an overlapping function with DNA-PKcs in limiting the lateral movement of the Ku ring along DNA.Nucleic acids research · 2026Article
- Systematic discovery of UFM1 receptors reveals a regulatory module in DNA repair directing non-homologous end-joining.Nature communications · 2026Article
- DNA-PK-mediated CRTC2 phosphorylation promotes NHEJ and suppresses antitumor immunity via relocation to repair complexes.Nature communications · 2026Article
- Parallel Activation and Interference CRISPR (PAIR) with Sequencing Uncovers DNA Repair Networks Guiding Precision Cell Engineering.bioRxiv : the preprint server for biology · 2026Article
- Nonhomologous end joining-the importance of end tethering and beyond.Genes & development · 2026Review
- DNA polymerase λ autoinhibition is relieved via Ku interaction during non-homologous end joining.Nucleic acids research · 2026Article
- DNA end configurations dictate synaptic complex formation during NHEJ-mediated end bridging.Nature communications · 2026Article
- MTHFD2 is required for DNA repair and implicated in LUAD radiotherapy resistance.Journal of translational medicine · 2026Article
- Bringing the ends together: cryo-EM structures of mycobacterial Ku in complex with DNA define its role in NHEJ synapsis.Nucleic acids research · 2026Article
- Structure of Bacillus subtilis Ku-mediated DNA synaptic complex.Nucleic acids research · 2026Article
- Cryo-EM structures of NHEJ assemblies with nucleosomes.Nature communications · 2025Article
- Oligomerisation of Ku from Mycobacterium tuberculosis promotes DNA synapsis.Nature communications · 2025Article
- Nonhomologous end-joining uses distinct mechanisms to repair each strand of a double strand break.Nature communications · 2025Article
- 53BP1-RIF1 and DNA-PKcs show distinct genetic interactions with diverse chromosomal break repair outcomes.Nature communications · 2025Article
- Transcriptional regulation of Ligase IV by an intronic regulatory element directs thymocyte development.Genes and immunity · 2025Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Siyu ChenDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
Linda LeeDepartment of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada.ORCID http://orcid.org/0000-0002-4744-7243
Tasmin NailaDepartment of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.
Susan FishbainDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
Annie WangDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
Alan E TomkinsonDepartment of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.ORCID http://orcid.org/0000-0002-2671-1711
Susan P Lees-MillerDepartment of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada.ORCID http://orcid.org/0000-0001-5809-2516
Yuan HeDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA. yuanhe@northwestern.edu.ORCID http://orcid.org/0000-0002-1455-3963
Northwestern University · USUniversity of Calgary · CAUniversity of New Mexico · US
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9MTranscription-Coupled & Replication-Associated Excision RepairP01CA092584 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI WALTER J. CHAZIN · 2001 to 2026
$89.6MWOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1MPacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8MSpatio-Temporal Organization of Chromatin and Information Transfer in CancerU54CA193419 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI O'HALLORAN, THOMAS V · 2015 to 2020
$10.4MCELLULAR FUNCTIONS OF EUKARYOTIC LIGASESR01GM047251 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI DAVIS, ANTHONY J, TOMKINSON, ALAN E · 1998 to 2021
$4.7MMolecular Biophysics Training Program at Northwestern UniversityT32GM008382 · NIGMS · NORTHWESTERN UNIVERSITY · PI RADHAKRISHNAN, ISHWAR · 1990 to 2020
$4.3MStructure and Mechanism of Non-Homologous End JoiningR01GM135651 · NIGMS · NORTHWESTERN UNIVERSITY · PI HE, YUAN · 2020 to 2024
$1.8MAcquisition of Amersham Typhoon 5 Variable-mode ImagerS10OD026963 · OD · NORTHWESTERN UNIVERSITY · PI GRIGORESCU, ARABELA A · 2019 to 2019
$143kNCI NIH HHS P01 CA092584NCI NIH HHS P30 CA060553NCI NIH HHS P30 CA118100NCI NIH HHS U54 CA193419NIGMS NIH HHS R01 GM047251NIGMS NIH HHS R01 GM135651NIGMS NIH HHS T32 GM008382NIGMS NIH HHS U24 GM129547NIH HHS S10 OD026963
Abstract
DNA double-strand breaks (DSBs) are a highly cytotoxic form of DNA damage and the incorrect repair of DSBs is linked to carcinogenesis
Indexed as
Cryoelectron MicroscopyDNA Breaks, Double-StrandedDNA End-Joining RepairDNADNA-Activated Protein KinaseDNA-Binding ProteinsDNA Ligase ATPDNA Repair EnzymesHumansKu AutoantigenModels, MolecularPhosphorylationDNADNA-Activated Protein KinaseDNA-Binding ProteinsDNA Ligase ATPDNA Repair EnzymesKu AutoantigenNHEJ1 protein, humanXRCC4 protein, humanXRCC5 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.