ArticleNature2021
AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity.
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.
0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
110 citing papers in PubMed, 152 citations in OpenAlex.
- Phase II Study of Palbociclib (PD-0332991) in CCND1, 2, or 3 Amplification: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol Z1B.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023Trial
- AMBRA1 allosterically activates NLRP3 by releasing its autoinhibition.Nature immunology · 2026Article
- Matrine Suppresses Lung Cancer Progression via Dual Inhibition of CHEK1-Mediated DNA Damage Repair and PI3K/AKT Survival Signaling.Thoracic cancer · 2026Article
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- Molecular modulators of cyclin-dependent kinase 4/6 inhibitor response in experimental glioma identified through genome-wide CRISPR-Cas9 screening.Neuro-oncology · 2026Article
- Article
- Ubiquitin-dependent degradation of p27Kip1 and p21Waf1/Cip1 by AMBRA1 ensures G1 and S phase progression and limits replication stress.Nucleic acids research · 2026Article
- Editing regulatory network in non-small cell lung cancer: implications for immunity and metastasis.Human genomics · 2026Article
- Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells.FEBS open bio · 2026Article
- A novel synthetic melanin as a potential anticancer agent that induces apoptosis and cyclin D downregulation through distinct pathways.The Journal of biological chemistry · 2026Article
- CRL4EMBO reports · 2026Article
- A Dual-Gene Signature of PMAIP1 and GADD45A for Early Detection of Intrahepatic Cholangiocarcinoma in the Context of Primary Sclerosing Cholangitis.International journal of molecular sciences · 2026Article
- Article
- AMBRA1 activation alleviates zearalenone-induced swine testicular cell ferroptosis by facilitating mitophagy.Journal of animal science and biotechnology · 2026Article
- A proteome-wide dependency map of protein interaction motifs.Nature structural & molecular biology · 2026Article
- Pre-dauer starvation rapidly and reversibly reduces niche proliferative signaling to the Caenorhabditis elegans germ line.Development (Cambridge, England) · 2026Article
- Multiple patient-derived glioblastoma models reveal synthetic lethality through concurrent PI3K and CDK4/6 inhibition by blocking trans-active cooperation.Neuro-oncology · 2026Article
- CRL4International journal of biological sciences · 2026Article
- Sumoylation of cyclin and its therapeutic potential for cancer.Animal cells and systems · 2026Review
- Mitophagy in the pathogenesis and management of disease.Cell research · 2026Review
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
46 authors at 16 institutions in 6 countries.
Emiliano Maiani *Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-1432-5394
Giacomo Milletti *Department of Pediatric Onco-Hematology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.ORCID http://orcid.org/0000-0003-2391-342X
Francesca NazioDepartment of Pediatric Onco-Hematology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Søs Grønbæk HoldgaardCell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, Denmark.
Jirina BartkovaGenome Integrity Unit, Danish Cancer Society Research Center, Copenhagen, Denmark.
Salvatore RizzaRedox Biology Group, Danish Cancer Society Research Center, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-7335-4684
Valentina CianfanelliCell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-3857-9463
Mar LorenteDepartment of Biochemistry and Molecular Biology, School of Biology, Complutense University, Madrid, Spain.
Daniele SimoneschiDepartment of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-0448-4295
Miriam Di MarcoComputational Biology Laboratory, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, Denmark.
Pasquale D'AcunzoCenter for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA.ORCID http://orcid.org/0000-0001-7237-0076
Luca Di LeoMelanoma Research Team, Cell Stress and Survival Unit, Danish Cancer Society Research Center, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-2419-2196
Rikke RasmussenBrain Tumor Biology Group, Danish Cancer Society Research Center, Copenhagen, Denmark.
Costanza MontagnaRedox Biology Group, Danish Cancer Society Research Center, Copenhagen, Denmark.
Marilena RacitiCell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, Denmark.
Cristiano De StefanisResearch Laboratories, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Estibaliz GabicagogeascoaDepartment of Biochemistry and Molecular Biology, School of Biology, Complutense University, Madrid, Spain.
Gergely RonaDepartment of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY, USA.
Nélida SalvadorDepartment of Biochemistry and Molecular Biology, School of Biology, Complutense University, Madrid, Spain.
Emanuela PupoCandiolo Cancer Institute, FPO - IRCCS, Turin, Italy.
Joanna Maria Merchut-MayaGenome Integrity Unit, Danish Cancer Society Research Center, Copenhagen, Denmark.
Colin J DanielDepartment of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA.
Marianna CarinciDepartment of Pediatric Onco-Hematology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Valeriana CesariniDepartment of Pediatric Onco-Hematology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Alfie O'sullivanDepartment of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY, USA.
Yeon-Tae JeongDepartment of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY, USA.
Matteo BordiDepartment of Pediatric Onco-Hematology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.ORCID http://orcid.org/0000-0001-8207-8546
Francesco RussoSection for Clinical Mass Spectrometry, Danish Center for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Silvia CampelloDepartment of Biology, University of Rome 'Tor Vergata', Rome, Italy.ORCID http://orcid.org/0000-0003-0536-2484
Angela GalloDepartment of Pediatric Onco-Hematology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Giuseppe FilomeniRedox Biology Group, Danish Cancer Society Research Center, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-2719-1412
Letizia LanzettiCandiolo Cancer Institute, FPO - IRCCS, Turin, Italy.ORCID http://orcid.org/0000-0001-7541-5524
Rosalie C SearsDepartment of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA.ORCID http://orcid.org/0000-0003-1558-2413
Petra HamerlikBrain Tumor Biology Group, Danish Cancer Society Research Center, Copenhagen, Denmark.
Armando BartolazziDepartment of Pathology and Pathology Research Laboratory, Sant'Andrea Hospital, Rome, Italy.ORCID http://orcid.org/0000-0001-7820-5127
Robert E HyndsCancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, University College London, London, UK.ORCID http://orcid.org/0000-0002-2170-8791
David R PearceCancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, University College London, London, UK.ORCID http://orcid.org/0000-0001-8443-2924
Charles SwantonCancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, University College London, London, UK.ORCID http://orcid.org/0000-0002-4299-3018
Michele PaganoDepartment of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY, USA.
Guillermo VelascoDepartment of Biochemistry and Molecular Biology, School of Biology, Complutense University, Madrid, Spain.ORCID http://orcid.org/0000-0002-1994-2386
Elena PapaleoComputational Biology Laboratory, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, Denmark.
Daniela De ZioMelanoma Research Team, Cell Stress and Survival Unit, Danish Cancer Society Research Center, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-9454-402X
Apolinar Maya-MendozaGenome Integrity Unit, Danish Cancer Society Research Center, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-7452-9896
Franco LocatelliDepartment of Pediatric Onco-Hematology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Jiri BartekGenome Integrity Unit, Danish Cancer Society Research Center, Copenhagen, Denmark. jb@cancer.dk.ORCID http://orcid.org/0000-0003-2013-7525
Francesco CecconiCell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, Denmark. cecconi@cancer.dk.ORCID http://orcid.org/0000-0002-5614-4359
Danish Cancer Society · DKBambino Gesù Children's Hospital · ITHoward Hughes Medical Institute · USUniversidad Complutense de Madrid · ESUniversity of Rome Tor Vergata · ITCandiolo Cancer Institute · ITOregon Health & Science University · USScience for Life Laboratory · SEThe Francis Crick Institute · GBCancer Research UK · GBCTO Andrea Alesini · ITFrederiksberg Hospital · DKNathan Kline Institute for Psychiatric Research · USStatens Serum Institut · DKUniversity of Copenhagen · DKUniversity of Ferrara · IT
Funding
F-Box Proteins: Deregulated Cell Cycle Control and Proteolysis in CancerR01CA076584 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PAGANO, MICHELE · 1998 to 2021
$4.5MHydroxylation regulation of c-MycR01CA186241 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Mu-Shui Dai, ROSALIE C SEARS · 2015 to 2026
$4.2MCellular Mechanisms Controlling Myc Protein StabilityR01CA100855 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI SEARS, ROSALIE C · 2003 to 2014
$3.6MRegulation of the cell proliferation by CRL ubiquitin ligases-diversity supplementR35GM136250 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MICHELE PAGANO · 2020 to 2026
$2.7MMedical Research Council FC001169NCI NIH HHS R01 CA076584NCI NIH HHS R01 CA100855NCI NIH HHS R01 CA186241NIGMS NIH HHS R35 GM136250Wellcome Trust 209199/Z/17/Z
Abstract
Mammalian development, adult tissue homeostasis and the avoidance of severe diseases including cancer require a properly orchestrated cell cycle, as well as error-free genome maintenance. The key cell-fate decision to replicate the genome is controlled by two major signalling pathways that act in parallel-the MYC pathway and the cyclin D-cyclin-dependent kinase (CDK)-retinoblastoma protein (RB) pathway
Indexed as
Genomic InstabilityS PhaseAdaptor Proteins, Signal TransducingAnimalsCell LineCell ProliferationCheckpoint Kinase 1Cyclin DCyclin-Dependent KinasesDNA ReplicationGene Expression Regulation, DevelopmentalGenes, Tumor SuppressorHumansMiceMice, KnockoutSynthetic Lethal MutationsAdaptor Proteins, Signal TransducingAMBRA1 protein, humanAmbra1 protein, mouseCheckpoint Kinase 1Chek1 protein, mouseCyclin DCyclin-Dependent Kinases
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.