Evidence map›Paper›PMID 33854174›Full record

ArticleScientific reports2021

Identification and functional analysis of a biflavone as a novel inhibitor of transient receptor potential vanilloid 4-dependent atherogenic processes.

Mazen O Alharbi, Bidisha Dutta, Rishov Goswami, Shweta Sharma, Kai Y Lei, Shaik O Rahaman

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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  10. TRPV4 facilitates the reprogramming of inflamed macrophages by regulating IL-10 production via CREB.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mazen O AlharbiDepartment of Nutrition and Food Science, University of Maryland, College Park, MD, 20742, USA.
Bidisha DuttaDepartment of Nutrition and Food Science, University of Maryland, College Park, MD, 20742, USA.
Rishov GoswamiDepartment of Nutrition and Food Science, University of Maryland, College Park, MD, 20742, USA.
Shweta SharmaDepartment of Nutrition and Food Science, University of Maryland, College Park, MD, 20742, USA.
Kai Y LeiDepartment of Nutrition and Food Science, University of Maryland, College Park, MD, 20742, USA.
Shaik O RahamanDepartment of Nutrition and Food Science, University of Maryland, College Park, MD, 20742, USA. srahaman@umd.edu.
University of Maryland, College Park · US

Funding

Role of TRPV4 mechanotransduction in foreign body responseR01EB024556 · NIBIB · UNIV OF MARYLAND, COLLEGE PARK · PI RAHAMAN, SHAIK O, ZHU, XIAOPING · 2017 to 2020
$1.7M
NIBIB NIH HHS R01 EB024556
6 · The paper itself

Abstract

Atherosclerosis, a chronic inflammatory disease of large arteries, is the major contributor to the growing burden of cardiovascular disease-related mortality and morbidity. During early atherogenesis, as a result of inflammation and endothelial dysfunction, monocytes transmigrate into the aortic intimal areas, and differentiate into lipid-laden foam cells, a critical process in atherosclerosis. Numerous natural compounds such as flavonoids and polyphenols are known to have anti-inflammatory and anti-atherogenic properties. Herein, using a fluorometric imaging plate reader-supported Ca

Indexed as

AnimalsAtherosclerosisBiflavonoidsCalciumCell LineFoam CellsHigh-Throughput Screening AssaysLipoproteins, LDLMiceMice, Inbred C57BLModels, BiologicalRAW 264.7 CellsTRPV Cation ChannelsBiflavonoidsCalciumginkgetinLipoproteins, LDLoxidized low density lipoproteinTrpv4 protein, mouseTRPV Cation Channels

Identifiers

PMID33854174
PMCPMC8047007
OpenAlexW3155422171

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.