ArticleScientific reports2021
Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Quantitative Imaging of the Heterogeneity of Brain Potassium Depletion in Experimental Focal Ischemia.bioRxiv : the preprint server for biology · 2026Article
- Spreading depolarization in neurocritical care: a review of SD'S pathophysiological continuum and clinical translation.Frontiers in human neuroscience · 2026Review
- Rodent and human seizures demonstrate a dynamic interplay with spreading depolarizations.Neurobiology of disease · 2025Article
- Article
- Brain State-Dependent Neocortico-Hippocampal Network Dynamics Are Modulated by Postnatal Stimuli.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Imaging the large-scale and cellular response to focal traumatic brain injury in mouse neocortex.Experimental physiology · 2025Article
- Glutamate load fosters spreading depolarization under osmotic stress in brain slices.Frontiers in cellular neuroscience · 2025Article
- Enhancing glymphatic fluid transport by pan-adrenergic inhibition suppresses epileptogenesis in male mice.Nature communications · 2024Article
- Imaging the large-scale and cellular response to focal traumatic brain injury in mouse neocortex.bioRxiv : the preprint server for biology · 2024Article
- Probing intracellular potassium dynamics in neurons with the genetically encoded sensor lc-LysM GEPII 1.0 in vitro and in vivo.Scientific reports · 2024Article
- Alterations in brain fluid physiology during the early stages of development of ischaemic oedema.Fluids and barriers of the CNS · 2024Review
- Dysregulation of extracellular potassium distinguishes healthy ageing from neurodegeneration.Brain : a journal of neurology · 2024Article
- Astrocyte regulation of extracellular space parameters across the sleep-wake cycle.Frontiers in cellular neuroscience · 2024Review
- Transcranial cortex-wide CaFrontiers in neuroscience · 2023Review
- Brain dysfunction during warming is linked to oxygen limitation in larval zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Human-in-the-Loop Optimization of Transcranial Electrical Stimulation at the Point of Care: A Computational Perspective.Brain sciences · 2022Article
- Depth-targeted intracortical microstroke by two-photon photothrombosis in rodent brain.Neurophotonics · 2022Article
- Cortical spreading depression: culprits and mechanisms.Experimental brain research · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Cortical spreading depolarization (CSD) is a propagating wave of tissue depolarization characterized by a large increase of extracellular potassium concentration and prolonged subsequent electrical silencing of neurons. Waves of CSD arise spontaneously in various acute neurological settings, including migraine aura and ischemic stroke. Recently, we have reported that pan-inhibition of adrenergic receptors (AdRs) facilitates the normalization of extracellular potassium after acute photothrombotic stroke in mice. Here, we have extended that mechanistic study to ask whether AdR antagonists also modify the dynamics of KCl-induced CSD and post-CSD recovery in vivo. Spontaneous neural activity and KCl-induced CSD were visualized by cortex-wide transcranial Ca
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