ArticleScientific reports2021
The absence of the caffeine synthase gene is involved in the naturally decaffeinated status of Coffea humblotiana, a wild species from Comoro archipelago.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 45 citations in OpenAlex.
- CsDRMH3 in tea plant (Camellia sinensis): functional study on mediating caffeine biosynthesis in relation to bud dormancy status.BMC plant biology · 2026Article
- Evolutionary history and climate-driven dynamics of transposable elements has shaped genome evolution in the Coffea genus.Scientific reports · 2026Article
- Genetic diversity and population structure ofFrontiers in plant science · 2026Article
- A Near Telomere-To-Telomere Genome Assembly of Coffea arabica (Mundo Novo) Provides Insights Into Its Secondary Metabolism.Molecular ecology resources · 2025Article
- A chromosome-level genome assembly of Coffea arabica L. var. 'Kona Typica'.Scientific data · 2025Article
- Sensory Classification of BrazilianACS omega · 2025Article
- Chromosome distribution of four LTR retrotransposons and 18 S rDNA in coffea eugenioides.Scientific reports · 2025Article
- A near-complete genome assembly of Cinchona calisaya.Scientific data · 2025Article
- Genome mining of metabolic gene clusters in the Rubiaceae family.Computational and structural biotechnology journal · 2024Article
- Evolution of the biochemistry underpinning purine alkaloid metabolism in plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Pathogen elicitor peptide (pep), systemin, and their receptors in tomato: sequence analysis sheds light on standing disagreements about biotic stress signaling components.BMC plant biology · 2024Article
- A chromosome-scale assembly reveals chromosomal aberrations and exchanges generating genetic diversity in Coffea arabica germplasm.Nature communications · 2024Article
- Convention on Biological Diversity (CBD) and the Nagoya Protocol: Implications and Compliance Strategies for the Global Coffee Community.Foods (Basel, Switzerland) · 2024Article
- High quality genomes produced from single MinION flow cells clarify polyploid and demographic histories of critically endangered Fraxinus (ash) species.Communications biology · 2024Article
- The evolutionary history of three Baracoffea species from western Madagascar revealed by chloroplast and nuclear genomes.PloS one · 2024Article
- Selection signatures and population dynamics of transposable elements in lima bean.Communications biology · 2023Article
- Inpactor2: a software based on deep learning to identify and classify LTR-retrotransposons in plant genomes.Briefings in bioinformatics · 2023Article
- Multiplex CRISPR/Cas9-mediated knockout of the phytoene desaturase gene in Coffea canephora.Scientific reports · 2022Article
- Automatic curation of LTR retrotransposon libraries from plant genomes through machine learning.Journal of integrative bioinformatics · 2022Article
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20 authors at 8 institutions in 6 countries.
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Abstract
Caffeine is the most consumed alkaloid stimulant in the world. It is synthesized through the activity of three known N-methyltransferase proteins. Here we are reporting on the 422-Mb chromosome-level assembly of the Coffea humblotiana genome, a wild and endangered, naturally caffeine-free, species from the Comoro archipelago. We predicted 32,874 genes and anchored 88.7% of the sequence onto the 11 chromosomes. Comparative analyses with the African Robusta coffee genome (C. canephora) revealed an extensive genome conservation, despite an estimated 11 million years of divergence and a broad diversity of genome sizes within the Coffea genus. In this genome, the absence of caffeine is likely due to the absence of the caffeine synthase gene which converts theobromine into caffeine through an illegitimate recombination mechanism. These findings pave the way for further characterization of caffeine-free species in the Coffea genus and will guide research towards naturally-decaffeinated coffee drinks for consumers.
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