ArticleScientific reports2021
Non-invasive characterization of complex coronary lesions.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Optimizing Non-invasive Fractional Flow Reserve Estimation with Machine Learning-Enhanced 1D Hemodynamic Modeling.Cardiovascular engineering and technology · 2026Article
- Haemodynamic predictors of lesion progression in non-ischaemic tandem coronary stenoses.AsiaIntervention · 2026Article
- Digital twins and digital models of the human circulatory system.Nature reviews bioengineering · 2026Article
- Optical coherence tomography-guided percutaneous coronary intervention compared to angiography-guided percutaneous coronary intervention for complex lesions.World journal of cardiology · 2025Article
- Simulation-based machine learning for real-time assessment of side-branch hemodynamics in coronary bifurcation lesions.The international journal of high performance computing applications · 2025Article
- Establishing Hemodynamic Convergence Framework for Coronary Digital Twins Under Realistic Dynamic Heart Rates.Physics of fluids (Woodbury, N.Y. : 1994) · 2025Article
- Digital twins for noninvasively measuring predictive markers of right heart failure.NPJ digital medicine · 2025Article
- Enhancing cardiac assessments: accurate and efficient prediction of quantitative fractional flow reserve.Frontiers in bioengineering and biotechnology · 2025Article
- Establishing the longitudinal hemodynamic mapping framework for wearable-driven coronary digital twins.NPJ digital medicine · 2024Article
- Surgical Modulation of Pulmonary Artery Shear Stress: A Patient-Specific CFD Analysis of the Norwood Procedure.Cardiovascular engineering and technology · 2024Article
- Diagnostic Performance of Coronary Angiography Derived Computational Fractional Flow Reserve.Journal of the American Heart Association · 2024Article
- Identifying When Steady-State Flow Simulations In Patient-Specific Coronaries Recapitulate Pulsatile Flow Dynamics.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2024Article
- Systematic characterization and automated alignment of coronary tree geometries.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2024Article
- Uncertainty quantification of the impact of peripheral arterial disease on abdominal aortic aneurysms in blood flow simulations.Journal of the Royal Society, Interface · 2024Article
- Cloud Computing to Enable Wearable-Driven Longitudinal Hemodynamic Maps.International Conference for High Performance Computing, Networking, Storage and Analysis : [proceedings]. SC (Conference : Supercomputing) · 2023Article
- Impact of TAVR on coronary artery hemodynamics using clinical measurements and image-based patient-specific in silico modeling.Scientific reports · 2023Article
- Computational fluid dynamics as supporting technology for coronary artery disease diagnosis and treatment: an international survey.Frontiers in cardiovascular medicine · 2023Article
- Interplay between Artificial Intelligence and Biomechanics Modeling in the Cardiovascular Disease Prediction.Biomedicines · 2022Review
- Characterization of hemodynamics in anomalous aortic origin of coronary arteries using patient-specific modeling.Journal of biomechanics · 2022Article
- Analysis identifying minimal governing parameters for clinically accurateFrontiers in medical technology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
Conventional invasive diagnostic imaging techniques do not adequately resolve complex Type B and C coronary lesions, which present unique challenges, require personalized treatment and result in worsened patient outcomes. These lesions are often excluded from large-scale non-invasive clinical trials and there does not exist a validated approach to characterize hemodynamic quantities and guide percutaneous intervention for such lesions. This work identifies key biomarkers that differentiate complex Type B and C lesions from simple Type A lesions by introducing and validating a coronary angiography-based computational fluid dynamic (CFD-CA) framework for intracoronary assessment in complex lesions at ultrahigh resolution. Among 14 patients selected in this study, 7 patients with Type B and C lesions were included in the complex lesion group including ostial, bifurcation, serial lesions and lesion where flow was supplied by collateral bed. Simple lesion group included 7 patients with lesions that were discrete, [Formula: see text] long and readily accessible. Intracoronary assessment was performed using CFD-CA framework and validated by comparing to clinically measured pressure-based index, such as FFR. Local pressure, endothelial shear stress (ESS) and velocity profiles were derived for all patients. We validates the accuracy of our CFD-CA framework and report excellent agreement with invasive measurements ([Formula: see text]). Ultra-high resolution achieved by the model enable physiological assessment in complex lesions and quantify hemodynamic metrics in all vessels up to 1mm in diameter. Importantly, we demonstrate that in contrast to traditional pressure-based metrics, there is a significant difference in the intracoronary hemodynamic forces, such as ESS, in complex lesions compared to simple lesions at both resting and hyperemic physiological states [n = 14, [Formula: see text]]. Higher ESS was observed in the complex lesion group ([Formula: see text] Pa) than in simple lesion group ([Formula: see text] Pa). Complex coronary lesions have higher ESS compared to simple lesions, such differential hemodynamic evaluation can provide much the needed insight into the increase in adverse outcomes for such patients and has incremental prognostic value over traditional pressure-based indices, such as FFR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.