Evidence map›Paper›PMID 33854067›Full record

ArticleNature communications2021

Comprehensive omic characterization of breast cancer in Mexican-Hispanic women.

Sandra L Romero-Cordoba, Ivan Salido-Guadarrama, Rosa Rebollar-Vega, Veronica Bautista-Piña, Carlos Dominguez-Reyes, Alberto Tenorio-Torres, Felipe Villegas-Carlos, Juan C Fernández-López, Laura Uribe-Figueroa, Luis Alfaro-Ruiz and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
24.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 291 citations in OpenAlex.

  1. Trial
  2. Total saponins fromJournal of ginseng research · 2026
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  8. Genomic ancestry and cancer among Latin Americans.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Sandra L Romero-Cordoba *Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico. sromero@iibiomedicas.unam.mx.ORCID 0000-0002-5591-696X
Ivan Salido-Guadarrama *Laboratorio de Biología Computacional, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.ORCID 0000-0001-5166-6222
Rosa Rebollar-Vega *Cancer Genomics Laboratory, National Institute of Genomic Medicine, México City, Mexico.ORCID 0000-0002-9293-5959
Veronica Bautista-PiñaInstituto de Enfermedades de la Mama FUCAM, Mexico City, México.
Carlos Dominguez-ReyesInstituto de Enfermedades de la Mama FUCAM, Mexico City, México.
Alberto Tenorio-TorresInstituto de Enfermedades de la Mama FUCAM, Mexico City, México.
Felipe Villegas-CarlosInstituto de Enfermedades de la Mama FUCAM, Mexico City, México.
Juan C Fernández-LópezComputational Genomics Laboratory, National Institute of Genomic Medicine, Mexico City, Mexico.ORCID 0000-0003-3680-4193
Laura Uribe-FigueroaCancer Genomics Laboratory, National Institute of Genomic Medicine, México City, Mexico.
Luis Alfaro-RuizCancer Genomics Laboratory, National Institute of Genomic Medicine, México City, Mexico.
Alfredo Hidalgo-MirandaCancer Genomics Laboratory, National Institute of Genomic Medicine, México City, Mexico. ahidalgo@inmegen.gob.mx.ORCID 0000-0003-2315-3977
National Institute of Genomic Medicine · MXInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MXInstituto Nacional de Enfermedades Respiratorias · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is a heterogeneous pathology, but the genomic basis of its variability remains poorly understood in populations other than Caucasians. Here, through DNA and RNA portraits we explored the molecular features of breast cancers in a set of Hispanic-Mexican (HM) women and compared them to public multi-ancestry datasets. HM patients present an earlier onset of the disease, particularly in aggressive clinical subtypes, compared to non-Hispanic women. The age-related COSMIC signature 1 was more frequent in HM women than in those from other ancestries. We found the AKT1

Indexed as

AdultAgedBreast NeoplasmsClass I Phosphatidylinositol 3-KinasesExome SequencingFemaleHispanic or LatinoHumansMexican AmericansMiddle AgedMutationProto-Oncogene Proteins c-aktAKT1 protein, humanClass I Phosphatidylinositol 3-KinasesPIK3CA protein, humanProto-Oncogene Proteins c-akt

Identifiers

PMID33854067
PMCPMC8046804
OpenAlexW3156143340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.