ArticleNature communications2021
Generating biomembrane-like local curvature in polymersomes via dynamic polymer insertion.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Fibroblast-Mimetic Lignin Polymersomes for Logic-Gated Synthesis of Mechanically Reconfigurable Bioskins.Angewandte Chemie (International ed. in English) · 2026Article
- Shaping Function: Polymeric 3D Systems With Unconventional Geometries for Biomedical Applications.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Bottom-up Strategies for Generating Polymer Protocells That Mimic Cellular Communication.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Coronal Complexation Induces Snowman-Shaped Janus Polymersome Formation.Angewandte Chemie (International ed. in English) · 2025Article
- Polymersome-based nanomotors: preparation, motion control, and biomedical applications.Chemical science · 2025Review
- pH/ Temperature/ Redox and Light-responsive Polymersome Structure and Application in Cancer Therapy: Smart Drug Delivery and Targeted Drug Release.Current medicinal chemistry · 2025Review
- Hot shape transformation: the role of PSar dehydration in stomatocyte morphogenesis.Beilstein journal of organic chemistry · 2025Article
- Biofilm Disruption from within: Light-Activated Molecular Drill-Functionalized Polymersomes Bridge the Gap between Membrane Damage and Quorum Sensing-Mediated Cell Death.ACS biomaterials science & engineering · 2024Article
- Shape Transformation of Polymer Vesicles.Accounts of materials research · 2024Article
- Controlled node growth on the surface of polymersomes.Chemical science · 2024Article
- Synthetic Cells Revisited: Artificial Cells Construction Using Polymeric Building Blocks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Dynamic metastable polymersomes enable continuous flow manufacturing.Nature communications · 2023Article
- Morphogenesis of starfish polymersomes.Nature communications · 2023Article
- Liposome Deformation Induced by Membrane-Binding Peptides.Micromachines · 2023Article
- Recent Advances in Drug Delivery System Fabricated by Microfluidics for Disease Therapy.Bioengineering (Basel, Switzerland) · 2022Review
- Membrane Manipulation of Giant Unilamellar Polymer Vesicles with a Temperature-Responsive Polymer.Angewandte Chemie (International ed. in English) · 2022Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomembrane curvature formation has long been observed to be essential in the change of membrane morphology and intracellular processes. The significant importance of curvature formation has attracted scientists from different backgrounds to study it. Although magnificent progress has been achieved using liposome models, the instability of these models restrict further exploration. Here, we report a new approach to mimic biomembrane curvature formation using polymersomes as a model, and poly(N-isopropylacrylamide) to induce the local curvature based on its co-nonsolvency phenomenon. Curvatures form when poly(N-isopropylacrylamide) becomes hydrophobic and inserts into the membrane through solvent addition. The insertion area can be fine-tuned by adjusting the poly(N-isopropylacrylamide) concentration, accompanied by the formation of new polymersome-based non-axisymmetric shapes. Moreover, a systematic view of curvature formation is provided through investigation of the segregation, local distribution and dissociation of inserted poly(N-isopropylacrylamide). This strategy successfully mimicks biomembrane curvature formation in polymersomes and a detailed observation of the insertion can be beneficial for a further understanding of the curvature formation process. Furthermore, polymer insertion induced shape changing could open up new routes for the design of non-axisymmetric nanocarriers and nanomachines to enrich the boundless possibilities of nanotechnology.
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