ArticleNPJ Parkinson's disease2021
Delayed orthostatic hypotension in Parkinson's disease.
Article in NPJ Parkinson's disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevalence and impact of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Pooled it
- Orthostatic hypotension in Parkinson's disease: effects on clinical features and disease severity-a systematic review and meta-analysis.Frontiers in aging neuroscience · 2025Pooled it
- Putative sympathetic-predominant subtype in body-first Parkinson's disease is associated with accelerated cognitive decline.Frontiers in aging neuroscience · 2026Article
- Approach to Cardiovascular Autonomic Dysfunction in Patients with Synucleinopathies.Movement disorders clinical practice · 2025Review
- Delayed orthostatic hypotension in Parkinson's disease and in the general ageing population.Age and ageing · 2025Article
- Orthostatic Hypotension and Risk of Mild Cognitive Impairment and Dementia in Parkinson's Disease.Movement disorders clinical practice · 2024Article
- Levodopa: From Biological Significance to Continuous Monitoring.ACS sensors · 2024Review
- Digital biomarkers for non-motor symptoms in Parkinson's disease: the state of the art.NPJ digital medicine · 2024Review
- Estimating motor progression trajectory pursuant to temporal dynamic status of cardiac denervation in Parkinson's disease.Journal of neurology · 2024Article
- A 3-year natural history of orthostatic blood pressure dysregulation in early Parkinson's disease.NPJ Parkinson's disease · 2023Article
- The differences of orthostatic hypotension in patients with Parkinson's disease and multiple system atrophy.Frontiers in neurology · 2023Article
- Predictive Value of Exercise Blood Pressure Changes for Orthostatic Hypotension in Patients With Parkinson's Disease.Journal of clinical neurology (Seoul, Korea) · 2023Article
- Caudate-anchored cognitive connectivity pursuant to orthostatic hypotension in early Parkinson's disease.Scientific reports · 2022Article
- Frequency and Factors Associated with Orthostatic Hypotension in Individuals with Parkinson's Disease: A Case-Control Observational Study.Ethiopian journal of health sciences · 2022Observational
- Corneal confocal microscopy differentiates patients with Parkinson's disease with and without autonomic involvement.NPJ Parkinson's disease · 2022Article
- Effect of Parkinson's Disease on Cardio-postural Coupling During Orthostatic Challenge.Frontiers in physiology · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Orthostatic hypotension (OH) is relatively common in the early stage of Parkinson's disease (PD). It is divided into delayed OH and classical OH. Classical OH in PD has been investigated widely, however, the clinical implications of delayed OH in PD have seldom been studied. The purpose of this study is to characterize delayed OH in PD. A total of 285 patients with early drug-naïve PD were enrolled and divided into three groups according to orthostatic change: no-OH, delayed OH, and classical OH. The disease severity in terms of motor, non-motor, and cognitive functions was assessed. The cortical thickness of 82 patients was analyzed with brain magnetic resonance imaging. The differences among groups and linear tendency in the order of no-OH, delayed OH, and classical OH were investigated. Seventy-seven patients were re-evaluated. Initial and follow-up evaluations were explored to discern any temporal effects of orthostasis on disease severity. Sixty-four (22.5%) patients were defined as having delayed OH and 117 (41.1%) had classical OH. Between-group comparisons revealed that classical OH had the worst outcomes in motor, non-motor, cognitive, and cortical thickness, compared to the other groups. No-OH and delayed OH did not differ significantly. Linear trends across the pre-ordered OH subtypes found that clinical parameters worsened along with the orthostatic challenge. Clinical scales deteriorated and the linear gradient was maintained during the follow-up period. This study suggests that delayed OH is a mild form of classical OH in PD. PD with delayed OH has milder disease severity and progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.