ArticleTranslational psychiatry2021
Intensification of functional neural control on heartbeat dynamics in subclinical depression.
Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Exploration of brain imaging biomarkers in subthreshold depression patients across different ages: an ALE meta-analysis based on MRI studies.BMC psychiatry · 2025Pooled it
- Heart rate variability status at rest in adult depressed patients: a systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- Altered Salience-Default Mode Network Dynamics in Subclinical Depression: A Preclustering-Based Co-Activation Pattern Analysis.CNS neuroscience & therapeutics · 2026Article
- Enhanced Brain-Heart Connectivity as a Precursor of Reduced State Anxiety after Therapeutic Virtual Reality Immersion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The brain-heart axis: integrative cooperation of neural, mechanical and biochemical pathways.Nature reviews. Cardiology · 2025Review
- Increased Modulation of Low-Frequency Cardiac Rhythms on Resting-State Left Insula Alpha Oscillations in Major Depressive Disorder: Evidence from a Magnetoencephalography Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A person-oriented approach to social anxiety and depression: latent profiles and emotional functioning in adults.Frontiers in psychology · 2025Article
- Individual Autonomic Profiles Influence Brain-Heart Connectivity in Tonic Pain.Journal of pain research · 2025Article
- Investigating heart rate variability measures during pregnancy as predictors of postpartum depression and anxiety: an exploratory study.Translational psychiatry · 2024Article
- Impaired brain-heart axis in focal epilepsy: Alterations in information flow and implications for seizure dynamics.Network neuroscience (Cambridge, Mass.) · 2024Article
- Sympathetic and parasympathetic central autonomic networks.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Chinese version of the Perth Alexithymia Questionnaire: psychometric properties and clinical applications.General psychiatry · 2024Article
- Microstates of the cortical brain-heart axis.Human brain mapping · 2023Article
- Dynamic fluctuations in ascending heart-to-brain communication under mental stress.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Modeling brain-heart interactions from Poincaré plot-derived measures of sympathetic-vagal activity.MethodsX · 2023Article
- Depression as a cardiovascular disorder: central-autonomic network, brain-heart axis, and vagal perspectives of low mood.Frontiers in network physiology · 2023Article
- Complex Brain-Heart Mapping in Mental and Physical Stress.IEEE journal of translational engineering in health and medicine · 2023Article
- Aberrant degree centrality of functional brain networks in subclinical depression and major depressive disorder.Frontiers in psychiatry · 2023Article
- Functional brain-heart interplay extends to the multifractal domain.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2021Article
- Detection of residual consciousness using EEG indicators related to rectal perception: protocol for a diagnostic accuracy study.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subclinical depression (dysphoria) is a common condition that may increase the risk of major depression and leads to impaired quality of life and severe comorbid somatic diseases. Despite its prevalence, specific biological markers are unknown; consequently, the identification of dysphoria currently relies exclusively on subjective clinical scores and structured interviews. Based on recent neurocardiology studies that link brain and cardiovascular disorders, it was hypothesized that multi-system biomarkers of brain-body interplay may effectively characterize dysphoria. Thus, an ad hoc computational technique was developed to quantify the functional bidirectional brain-heart interplay. Accordingly, 32-channel electroencephalographic and heart rate variability series were obtained from 24 young dysphoric adults and 36 healthy controls. All participants were females of a similar age, and results were obtained during a 5-min resting state. The experimental results suggest that a specific feature of dysphoria is linked to an augmented functional central-autonomic control to the heart, which originates from central, frontopolar, and occipital oscillations and acts through cardiovascular sympathovagal activity. These results enable further development of a large set of novel biomarkers for mood disorders based on comprehensive brain-body measurements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.