Evidence map›Paper›PMID 33853957›Full record

ArticleJournal of virology2021

Enhancement of Antibody-Dependent Cellular Cytotoxicity and Phagocytosis in Anti-HIV-1 Human-Bovine Chimeric Broadly Neutralizing Antibodies.

Jack M Edwards, Behnaz Heydarchi, Georges Khoury, Natalia A Salazar-Quiroz, Christopher A Gonelli, Bruce Wines, P Mark Hogarth, Anne B Kristensen, Matthew S Parsons, Damian F J Purcell

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Engineering of CD8mBio · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Jack M Edwards *Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, VIC, Australia.
Behnaz Heydarchi *Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, VIC, Australia.
Georges KhouryDivision of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Natalia A Salazar-QuirozDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, VIC, Australia.
Christopher A GonelliDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, VIC, Australia.
Bruce WinesImmune Therapies Group, Burnet Institute, Melbourne, VIC, Australia.
P Mark HogarthImmune Therapies Group, Burnet Institute, Melbourne, VIC, Australia.
Anne B KristensenDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, VIC, Australia.
Matthew S ParsonsDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, VIC, Australia.
Damian F J PurcellDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, VIC, Australia.
The University of Melbourne · AUBurnet Institute · AUEmory University · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
HHS | National Institutes of Health (NIH) P51OD011132NIH HHS P51 OD011132
6 · The paper itself

Abstract

No prophylactic vaccine has provided robust protection against human immunodeficiency virus type 1 (HIV-1). Vaccine-induced broadly neutralizing antibodies (bNAbs) have not been achieved in humans and most animals; however, cows vaccinated with HIV-1 envelope trimers produce bNAbs with unusually long third heavy complementarity-determining regions (CDRH3s). Alongside neutralization, Fc-mediated effector functions, including antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADP), may be critical for

Indexed as

AnimalsAntibody-Dependent Cell CytotoxicityBroadly Neutralizing AntibodiesCattleCell LineHIV-1HIV AntibodiesHIV InfectionsHumansImmunoglobulin GKiller Cells, NaturalPhagocytosisProtein EngineeringReceptors, IgGRecombinant Fusion ProteinsBroadly Neutralizing AntibodiesFc gamma receptor IIAFCGR3A protein, humanHIV AntibodiesImmunoglobulin GReceptors, IgGRecombinant Fusion Proteinsantibody-dependent cellular cytotoxicityantibody-dependent phagocytosisbiotechnologyHIVmonoclonal antibodiesneutralizing antibodies

Identifiers

PMID33853957
PMCPMC8316091
OpenAlexW3155422250

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.