Evidence map›Paper›PMID 33853939›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Parental bias in expression and interaction of genes in the equine placenta.

Pouya Dini, Theodore Kalbfleisch, José M Uribe-Salazar, Mariano Carossino, Hossam El-Sheikh Ali, Shavahn C Loux, Alejandro Esteller-Vico, Jamie K Norris, Lakshay Anand, Kirsten E Scoggin and 5 more

Open access · bronzeAbstract readDataset
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. DNA Methylation ofBiology · 2025
    Article
  4. Article
  5. Single-nuclei RNA sequencing (snRNA-seq) uncovers trophoblast cell types and lineages in the mature bovine placenta.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 4 countries.

Pouya DiniGluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40503.ORCID 0000-0001-5553-5967
Theodore KalbfleischDepartment of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY 40202.ORCID 0000-0002-2370-8189
José M Uribe-SalazarDepartment of Biochemistry and Molecular Medicine, Genome Center, Medical Investigation of Neurodevelopmental Disorders Institute, University of California, Davis, CA 95616.ORCID 0000-0003-4875-818X
Mariano CarossinoGluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40503.ORCID 0000-0003-3864-5915
Hossam El-Sheikh AliGluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40503.ORCID 0000-0003-1677-488X
Shavahn C LouxGluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40503.ORCID 0000-0001-5193-6675
Alejandro Esteller-VicoGluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40503.
Jamie K NorrisGluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40503.ORCID 0000-0003-4759-5534
Lakshay AnandEnvironmental Epigenetics and Genetics Group, Department of Horticulture, University of Kentucky, Lexington, KY 40546.
Kirsten E ScogginGluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40503.
Carlos M Rodriguez LopezEnvironmental Epigenetics and Genetics Group, Department of Horticulture, University of Kentucky, Lexington, KY 40546.ORCID 0000-0002-9704-9788
James BreenSouth Australian Health and Medical Research Institute, Adelaide, SA 5001, Australia.
Ernest BaileyGluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40503.ORCID 0000-0001-8246-9117
Peter DaelsDepartment of Veterinary Medical Imaging and Small Animal Orthopaedics, Faculty of Veterinary Medicine, Ghent University, Merelbeke 9820, Belgium.ORCID 0000-0001-7884-0307
Barry A BallGluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40503; b.a.ball@uky.edu.
University of Kentucky · USGhent University · BENeuroDevelopment Center · USSouth Australian Health and Medical Research Institute · AUUniversity of Louisville · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most autosomal genes in the placenta show a biallelic expression pattern. However, some genes exhibit allele-specific transcription depending on the parental origin of the chromosomes on which the copy of the gene resides. Parentally expressed genes are involved in the reciprocal interaction between maternal and paternal genes, coordinating the allocation of resources between fetus and mother. One of the main challenges of studying parental-specific allelic expression (allele-specific expression [ASE]) in the placenta is the maternal cellular remnant at the fetomaternal interface. Horses (

Indexed as

AllelesAnimalsFemaleGene ExpressionGene Expression Regulation, DevelopmentalGenomic ImprintingHorsesPlacentaPlacentationPregnancyallele-specific expressionequinemonoallelic gene expressionparental gene expressionplacenta

Identifiers

PMID33853939
PMCPMC8072238
OpenAlexW3156369825

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.