ArticleNeurology2021
Association of Neighborhood Context, Cognitive Decline, and Cortical Change in an Unimpaired Cohort.
Abstract read
In one paragraph
Article in Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed.
- Trial
- Multimorbidity, Polypharmacy, and Neighborhood Disadvantage as Determinants of Cognitive Performance in the ARCHES Cohort.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026Article
- Individual-level Social Vulnerability and Cognitive Function Among Older Adults in the United States National Health and Nutrition Examination Survey.medRxiv : the preprint server for health sciences · 2026Article
- Catalyzing real-world change through exposome research.Neurotoxicology · 2026Review
- Assessing racial disparities in dementia-related vulnerabilities: a machine learning analysis of social, environmental, and climate factors.Ethnicity & health · 2026Article
- Loneliness Moderates the Association between Neighborhood Disadvantage and Cognitive Function Among Older Adults.Delaware journal of public health · 2026Article
- Young adult urbanicity, late midlife neighborhood disadvantage, and cognitive functioning in community-dwelling older men.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- High-resolution MRI evidence for age- and sex-related changes in hippocampal subfield volume during healthy aging.GeroScience · 2026Article
- The Modifying Effect of Individual-Level Neighborhood Perceptions on the Relationship Between Census-Level Neighborhood Social Vulnerability and Cognition in Older Latinos.International journal of environmental research and public health · 2026Article
- Spatial heterogeneity and influencing factors of cognitive impairment among elderly hypertensive patients: evidence from rural communities in China.BMC geriatrics · 2026Article
- Perceptions About Housing and Neighborhood Characteristics Among Aging Adult Black Americans in Two Predominantly Black, Low-Income Neighborhoods in Pittsburgh: A Multi-Method Analysis.Journal of racial and ethnic health disparities · 2026Article
- The role of social context in cognitive and neurobehavioural outcomes in epilepsy.Nature reviews. Neurology · 2026Review
- Midlife and late-life neighborhood socioeconomic status and cognitive function in later life: Differences by race.Annals of epidemiology · 2026Article
- Association of cumulative deficit frailty with brain age and Alzheimer's disease-related brain structure starting in late-middle age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- The long-term association of childhood neighborhood quality on cognitive function in later life: the mediating role of domestic violence.BMC psychology · 2026Article
- Older adults in more disadvantaged neighborhoods exhibit brain vascular dysfunction.Cerebral circulation - cognition and behavior · 2026Article
- Sociodemographic correlates of cognition and Alzheimer's disease and vascular biomarkers among middle to older age participants in the Healthy Brain Initiative.Journal of Alzheimer's disease : JAD · 2025Article
- Associations of Place-based Social Determinants of Health with Biomarkers of Alzheimer's Disease and Related Dementias.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2025Article
- SLEEP AND NEURODEGENERATION: EXAMINING POTENTIAL PHYSIOLOGICAL MECHANISMS.Current sleep medicine reports · 2025Article
- Higher neighborhood deprivation is associated with accelerated disease progression in behavioral-variant frontotemporal degeneration.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2025Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Jack F V HuntFrom the Wisconsin Alzheimer's Disease Research Center (J.F.V.H., N.M.V., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., O.O., S.C.J., S.A., B.B.B.), Department of Medicine, Geriatrics Division (W.R.B., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Health Services and Care Research Program (W.R.B., A.J.H.K.), and Department of Biostatistics & Medical Informatics (M.Y.), University of Wisconsin School of Medicine and Public Health; University of Wisconsin School of Nursing (M.Z.); and Geriatric Research Education and Clinical Center (GRECC) (L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), William S. Middleton Hospital, United States Department of Veterans Affairs, Madison, WI.ORCID 0000-0002-5719-9028
Nicholas M VogtFrom the Wisconsin Alzheimer's Disease Research Center (J.F.V.H., N.M.V., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., O.O., S.C.J., S.A., B.B.B.), Department of Medicine, Geriatrics Division (W.R.B., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Health Services and Care Research Program (W.R.B., A.J.H.K.), and Department of Biostatistics & Medical Informatics (M.Y.), University of Wisconsin School of Medicine and Public Health; University of Wisconsin School of Nursing (M.Z.); and Geriatric Research Education and Clinical Center (GRECC) (L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), William S. Middleton Hospital, United States Department of Veterans Affairs, Madison, WI.
Erin M JonaitisFrom the Wisconsin Alzheimer's Disease Research Center (J.F.V.H., N.M.V., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., O.O., S.C.J., S.A., B.B.B.), Department of Medicine, Geriatrics Division (W.R.B., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Health Services and Care Research Program (W.R.B., A.J.H.K.), and Department of Biostatistics & Medical Informatics (M.Y.), University of Wisconsin School of Medicine and Public Health; University of Wisconsin School of Nursing (M.Z.); and Geriatric Research Education and Clinical Center (GRECC) (L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), William S. Middleton Hospital, United States Department of Veterans Affairs, Madison, WI.
William R BuckinghamFrom the Wisconsin Alzheimer's Disease Research Center (J.F.V.H., N.M.V., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., O.O., S.C.J., S.A., B.B.B.), Department of Medicine, Geriatrics Division (W.R.B., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Health Services and Care Research Program (W.R.B., A.J.H.K.), and Department of Biostatistics & Medical Informatics (M.Y.), University of Wisconsin School of Medicine and Public Health; University of Wisconsin School of Nursing (M.Z.); and Geriatric Research Education and Clinical Center (GRECC) (L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), William S. Middleton Hospital, United States Department of Veterans Affairs, Madison, WI.
Rebecca L KoscikFrom the Wisconsin Alzheimer's Disease Research Center (J.F.V.H., N.M.V., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., O.O., S.C.J., S.A., B.B.B.), Department of Medicine, Geriatrics Division (W.R.B., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Health Services and Care Research Program (W.R.B., A.J.H.K.), and Department of Biostatistics & Medical Informatics (M.Y.), University of Wisconsin School of Medicine and Public Health; University of Wisconsin School of Nursing (M.Z.); and Geriatric Research Education and Clinical Center (GRECC) (L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), William S. Middleton Hospital, United States Department of Veterans Affairs, Madison, WI.
Megan ZuelsdorffFrom the Wisconsin Alzheimer's Disease Research Center (J.F.V.H., N.M.V., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., O.O., S.C.J., S.A., B.B.B.), Department of Medicine, Geriatrics Division (W.R.B., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Health Services and Care Research Program (W.R.B., A.J.H.K.), and Department of Biostatistics & Medical Informatics (M.Y.), University of Wisconsin School of Medicine and Public Health; University of Wisconsin School of Nursing (M.Z.); and Geriatric Research Education and Clinical Center (GRECC) (L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), William S. Middleton Hospital, United States Department of Veterans Affairs, Madison, WI.
Lindsay R ClarkFrom the Wisconsin Alzheimer's Disease Research Center (J.F.V.H., N.M.V., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., O.O., S.C.J., S.A., B.B.B.), Department of Medicine, Geriatrics Division (W.R.B., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Health Services and Care Research Program (W.R.B., A.J.H.K.), and Department of Biostatistics & Medical Informatics (M.Y.), University of Wisconsin School of Medicine and Public Health; University of Wisconsin School of Nursing (M.Z.); and Geriatric Research Education and Clinical Center (GRECC) (L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), William S. Middleton Hospital, United States Department of Veterans Affairs, Madison, WI.
Carey E GleasonFrom the Wisconsin Alzheimer's Disease Research Center (J.F.V.H., N.M.V., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., O.O., S.C.J., S.A., B.B.B.), Department of Medicine, Geriatrics Division (W.R.B., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Health Services and Care Research Program (W.R.B., A.J.H.K.), and Department of Biostatistics & Medical Informatics (M.Y.), University of Wisconsin School of Medicine and Public Health; University of Wisconsin School of Nursing (M.Z.); and Geriatric Research Education and Clinical Center (GRECC) (L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), William S. Middleton Hospital, United States Department of Veterans Affairs, Madison, WI.
Menggang YuFrom the Wisconsin Alzheimer's Disease Research Center (J.F.V.H., N.M.V., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., O.O., S.C.J., S.A., B.B.B.), Department of Medicine, Geriatrics Division (W.R.B., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Health Services and Care Research Program (W.R.B., A.J.H.K.), and Department of Biostatistics & Medical Informatics (M.Y.), University of Wisconsin School of Medicine and Public Health; University of Wisconsin School of Nursing (M.Z.); and Geriatric Research Education and Clinical Center (GRECC) (L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), William S. Middleton Hospital, United States Department of Veterans Affairs, Madison, WI.
Ozioma OkonkwoFrom the Wisconsin Alzheimer's Disease Research Center (J.F.V.H., N.M.V., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., O.O., S.C.J., S.A., B.B.B.), Department of Medicine, Geriatrics Division (W.R.B., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Health Services and Care Research Program (W.R.B., A.J.H.K.), and Department of Biostatistics & Medical Informatics (M.Y.), University of Wisconsin School of Medicine and Public Health; University of Wisconsin School of Nursing (M.Z.); and Geriatric Research Education and Clinical Center (GRECC) (L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), William S. Middleton Hospital, United States Department of Veterans Affairs, Madison, WI.
Sterling C JohnsonFrom the Wisconsin Alzheimer's Disease Research Center (J.F.V.H., N.M.V., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., O.O., S.C.J., S.A., B.B.B.), Department of Medicine, Geriatrics Division (W.R.B., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Health Services and Care Research Program (W.R.B., A.J.H.K.), and Department of Biostatistics & Medical Informatics (M.Y.), University of Wisconsin School of Medicine and Public Health; University of Wisconsin School of Nursing (M.Z.); and Geriatric Research Education and Clinical Center (GRECC) (L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), William S. Middleton Hospital, United States Department of Veterans Affairs, Madison, WI.
Sanjay AsthanaFrom the Wisconsin Alzheimer's Disease Research Center (J.F.V.H., N.M.V., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., O.O., S.C.J., S.A., B.B.B.), Department of Medicine, Geriatrics Division (W.R.B., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Health Services and Care Research Program (W.R.B., A.J.H.K.), and Department of Biostatistics & Medical Informatics (M.Y.), University of Wisconsin School of Medicine and Public Health; University of Wisconsin School of Nursing (M.Z.); and Geriatric Research Education and Clinical Center (GRECC) (L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), William S. Middleton Hospital, United States Department of Veterans Affairs, Madison, WI.
Barbara B BendlinFrom the Wisconsin Alzheimer's Disease Research Center (J.F.V.H., N.M.V., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., O.O., S.C.J., S.A., B.B.B.), Department of Medicine, Geriatrics Division (W.R.B., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Health Services and Care Research Program (W.R.B., A.J.H.K.), and Department of Biostatistics & Medical Informatics (M.Y.), University of Wisconsin School of Medicine and Public Health; University of Wisconsin School of Nursing (M.Z.); and Geriatric Research Education and Clinical Center (GRECC) (L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), William S. Middleton Hospital, United States Department of Veterans Affairs, Madison, WI. ajk@medicine.wisc.edu bbb@medicine.wisc.edu.
Amy J H KindFrom the Wisconsin Alzheimer's Disease Research Center (J.F.V.H., N.M.V., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., O.O., S.C.J., S.A., B.B.B.), Department of Medicine, Geriatrics Division (W.R.B., M.Z., L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), Health Services and Care Research Program (W.R.B., A.J.H.K.), and Department of Biostatistics & Medical Informatics (M.Y.), University of Wisconsin School of Medicine and Public Health; University of Wisconsin School of Nursing (M.Z.); and Geriatric Research Education and Clinical Center (GRECC) (L.R.C., C.E.G., O.O., S.C.J., S.A., B.B.B., A.J.H.K.), William S. Middleton Hospital, United States Department of Veterans Affairs, Madison, WI. ajk@medicine.wisc.edu bbb@medicine.wisc.edu.
Funding
University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9MThe Neighborhoods Study: Contextual Disadvantage and Alzheimer’s Disease and Related Dementias (ADRD)R01AG070883 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI AMY J. KIND · 2021 to 2026
$42.1MWisconsin Registry for Alzheimer's Prevention: Sex Differences in DNA MethylationR01AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Nathaniel Ark Chin, Sterling C Johnson · 2007 to 2026
$35.6MWisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI RICHARD J CHAPPELL · 2019 to 2026
$34.5MINSTITUTIONAL CTSA (UW-MADISON): CLINICAL TRIALSUL1RR025011 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2007 to 2011
$29.5MThe Longitudinal Course of Neural Function and Amyloid in People At Risk for ADR01AG021155 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sterling C Johnson · 2004 to 2026
$27.0MWisconsin Registry for Alzheimer's PreventionRF1AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI JOHNSON, STERLING C · 2018 to 2018
$18.8MWisconsin Alzheimer's Disease Research CenterP50AG033514 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CHAPPELL, RICHARD J · 2009 to 2018
$16.2MAfrican Americans Fighting Alzheimer’s in Midlife (AA-FAIM)R01AG054059 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CAREY E GLEASON · 2016 to 2026
$15.3MINTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTST32GM008692 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E · 1998 to 2020
$10.3MWhite matter degeneration: biomarkers in preclinical Alzheimer's DiseaseR01AG037639 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI BENDLIN, BARBARA BRIGITTA · 2012 to 2023
$5.3MNeighborhood Socioeconomic Contextual Disadvantage and Alzheimer's DiseaseRF1AG057784 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI BENDLIN, BARBARA BRIGITTA, KIND, AMY J. · 2017 to 2017
$3.8MNCATS NIH HHS UL1 TR002373NCRR NIH HHS UL1 RR025011NIA NIH HHS F30 AG059346NIA NIH HHS F31 AG062116NIA NIH HHS P30 AG062715NIA NIH HHS P50 AG033514NIA NIH HHS R01 AG021155NIA NIH HHS R01 AG027161NIA NIH HHS R01 AG037639NIA NIH HHS R01 AG054059NIA NIH HHS R01 AG070883NIA NIH HHS R56 AG037639NIA NIH HHS RF1 AG027161NIA NIH HHS RF1 AG057784NIGMS NIH HHS T32 GM008692NIMHD NIH HHS R01 MD010243
Abstract
objectiveTo test the hypothesis that neighborhood-level disadvantage is associated with longitudinal measures of neurodegeneration and cognitive decline in an unimpaired cohort.
methodsLongitudinal MRI and cognitive testing data were collected from 601 cognitively unimpaired participants in the Wisconsin Registry for Alzheimer's Prevention Study and the Wisconsin Alzheimer's Disease Research Center clinical cohort. Area Deprivation Index was geospatially determined based on participant residence geocode and ranked relative to state of residence. Linear regression models were fitted to test associations between neighborhood-level disadvantage and longitudinal change in cortical thickness and cognitive test performance. Mediation tests were used to assess whether neurodegeneration and cognitive decline were associated with neighborhood-level disadvantage along the same theoretical causal path.
resultsIn our middle- to older-aged study population (mean baseline age 59 years), living in the 20% most disadvantaged neighborhoods (n = 19) relative to state of residence was associated with cortical thinning in Alzheimer signature regions (
conclusionsIn this longitudinal study of cognitively unimpaired adults, living in the most highly disadvantaged neighborhoods was associated with accelerated degeneration in Alzheimer signature regions and cognitive decline. This study provides further evidence for neighborhood-level disadvantage as a risk factor for preclinical neurodegeneration and cognitive decline in certain populations. Limitations of the present study, including a small number of participants from highly disadvantaged neighborhoods and a circumscribed geographic setting, should be explored in larger and more diverse study cohorts.
Indexed as
AdultAgedAged, 80 and overBrain Cortical ThicknessCerebral Cortical ThinningCognitionCognitive DysfunctionEducational StatusEmploymentFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological Tests
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.