Evidence map›Paper›PMID 33853871›Full record

ArticlemSphere2021

B Cell Receptor-Responsive miR-141 Enhances Epstein-Barr Virus Lytic Cycle via FOXO3 Inhibition.

Yan Chen, Devin N Fachko, Nikita S Ivanov, Rebecca L Skalsky

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yan ChenVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA.
Devin N FachkoVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA.
Nikita S IvanovVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA.
Rebecca L SkalskyVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA skalsky@ohsu.edu.ORCID 0000-0003-2967-9478
Children's Cancer Therapy Development Institute · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
microRNA Regulation of Gamma-herpesvirus Latency and ReactivationR01AI143620 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI SKALSKY, REBECCA L · 2019 to 2023
$2.5M
The Role of Viral and Cellular miRNAs in B-cell LymphomagenesisR00CA175181 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI SKALSKY, REBECCA L · 2016 to 2018
$717k
The role of viral and cellular miRNAs in B-cell lymphomagenesisK99CA175181 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI SKALSKY, REBECCA L · 2014 to 2015
$199k
NCI NIH HHS K99 CA175181NCI NIH HHS R00 CA175181NIAID NIH HHS R01 AI143620NIH HHS P51 OD011092
6 · The paper itself

Abstract

Antigen recognition by the B cell receptor (BCR) is a physiological trigger for reactivation of Epstein-Barr virus (EBV) and can be recapitulated

Indexed as

B-LymphocytesCell LineForkhead Box Protein O3HEK293 CellsHerpesvirus 4, HumanHost-Pathogen InteractionsHumansMicroRNAsReceptors, Antigen, B-CellSignal TransductionVirus ActivationVirus Physiological PhenomenaForkhead Box Protein O3FOXO3 protein, humanMicroRNAsMIRN141 microRNA, humanReceptors, Antigen, B-CellEpstein-Barr virusFOXO3herpesviruseslatencylymphomamicroRNA

Identifiers

PMID33853871
PMCPMC8546685
OpenAlexW3156637462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.