ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2021
Grandmaternal Perinatal Serum DDT in Relation to Granddaughter Early Menarche and Adult Obesity: Three Generations in the Child Health and Development Studies Cohort.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Prenatal exposure to persistent organic pollutants and childhood obesity: A systematic review and meta-analysis of human studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Pooled it
- A Call for Training Pediatric Practitioners About Industrial Chemicals and Child Health.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026Article
- Occupation Associated with Altered Steroid Hormone Metabolism in Men: A Cross-Sectional Metabolome-Wide Association Study.Research square · 2026Article
- Obesogens in Prostate Cancer: An Endocrine and Metabolic Threat.Current obesity reports · 2026Review
- Geospatial and Temporal Inventory for Industrial DDT Waste Disposal to a Deep Coastal Ocean Environment.Environmental science & technology · 2025Article
- Associations of area-level and individual-level sociodemographic factors with adolescent phenotypes linked to subsequent cancer risk.Reproductive toxicology (Elmsford, N.Y.) · 2025Article
- Extremophile hotspots linked to containerized industrial waste dumping in a deep-sea basin.PNAS nexus · 2025Article
- Grandmaternal perinatal serum polychlorinated biphenyls and prevalence of obesity in adult daughters and granddaughters.Obesity (Silver Spring, Md.) · 2025Article
- Consensus on the key characteristics of metabolism disruptors.Nature reviews. Endocrinology · 2025Review
- Thematic Review of Endocrine Disruptors and Their Role in Shaping Pubertal Timing.Children (Basel, Switzerland) · 2025Review
- Reproductive toxicity of DDT in the Japanese medaka fish model: Revisiting the impacts of DDT+ on female reproductive health.Chemosphere · 2024Review
- Disentangling the History of Deep Ocean Disposal for DDT and Other Industrial Waste Off Southern California.Environmental science & technology · 2024Article
- Invited Perspective: Is DDT's Imprint Here to Stay?Environmental health perspectives · 2024Article
- Impaired energy expenditure following exposure to either DDT or DDE in mice may be mediated by DNA methylation changes in brown adipose.Environmental epigenetics · 2024Article
- Impact of Chemicals on the Age of Menarche: A Literature Review.Children (Basel, Switzerland) · 2023Review
- Obesogens and Obesity: State-of-the-Science and Future Directions Summary from a Healthy Environment and Endocrine Disruptors Strategies Workshop.The American journal of clinical nutrition · 2023Article
- The oral repellent - science fiction or common sense? Insects, vector-borne diseases, failing strategies, and a bold proposition.Tropical diseases, travel medicine and vaccines · 2023Review
- Persistent Organic Pollutant Levels in Maternal and Cord Blood Plasma and Breast Milk: Results from the Rio Birth Cohort Pilot Study of Environmental Exposure and Childhood Development (PIPA Study).International journal of environmental research and public health · 2022Article
- Maternal Diet Quality and the Health Status of Newborns.Foods (Basel, Switzerland) · 2022Article
- Maternal gut microbiota mediate intergenerational effects of high-fat diet on descendant social behavior.Cell reports · 2022Article
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4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSerum DDTs during or just after pregnancy were associated with breast cancer in mothers (F0), and with breast cancer, mammographic density, and obesity in adult daughters (F1) in the Child Health and Development Studies multi-generational cohort in prior publications. Here, we investigate F0 perinatal serum DDT associations with granddaughters'(F2) measured obesity at a median age of 26 and self-reported age at menarche.
methodsF2 weight, height and waist circumference were measured by trained examiners.
resultsF0
conclusionsAncestral exposure to environmental chemicals, banned decades ago, may influence the development of earlier menarche and obesity, which are established risk factors for breast cancer and cardiometabolic diseases. IMPACT: Discovery of actionable biomarkers of response to ancestral environmental exposures in young women may provide opportunities for breast cancer prevention.
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