Evidence map›Paper›PMID 33853825›Full record

ArticleCancer immunology research2021

Virus-Like Particle-Drug Conjugates Induce Protective, Long-lasting Adaptive Antitumor Immunity in the Absence of Specifically Targeted Tumor Antigens.

Rhonda C Kines, Cynthia D Thompson, Sean Spring, Zhenyu Li, Elisabet de Los Pinos, Stephen Monks, John T Schiller

Open access · bronzeAbstract read
In one paragraph

Article in Cancer immunology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rhonda C KinesAura Biosciences, Cambridge, Massachusetts. rkines@aurabiosciences.com.
Cynthia D ThompsonLaboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Sean SpringAura Biosciences, Cambridge, Massachusetts.
Zhenyu LiAura Biosciences, Cambridge, Massachusetts.
Elisabet de Los PinosAura Biosciences, Cambridge, Massachusetts.ORCID 0000-0001-7586-002X
Stephen MonksAura Biosciences, Cambridge, Massachusetts.
John T SchillerLaboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Axios Biosciences (United States) · USNational Institutes of Health · US

Funding

Understanding Papillomavirus Virion Proteins and VaccinesZIABC009052 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SCHILLER, JOHN T. · 2009 to 2025
$38.4M
Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

This study examined the ability of a papillomavirus-like particle drug conjugate, belzupacap sarotalocan (AU-011), to eradicate subcutaneous tumors after intravenous injection and to subsequently elicit long-term antitumor immunity in the TC-1 syngeneic murine tumor model. Upon

Indexed as

ImmunotherapyAdaptive ImmunityAnimalsAntigens, NeoplasmCancer VaccinesCD8-Positive T-LymphocytesCell Line, TumorCombined Modality TherapyDrug SynergismFemaleHumansImmune Checkpoint InhibitorsInfrared RaysLeukocytes, MononuclearMiceMice, Inbred C57BLAntigens, NeoplasmCancer VaccinesImmune Checkpoint InhibitorsVaccines, Virus-Like Particle

Identifiers

PMID33853825
PMCPMC8355054
OpenAlexW3155034531

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.