Evidence map›Paper›PMID 33853624›Full record

ArticleEnvironmental health : a global access science source2021

Childhood traffic-related air pollution and adverse changes in subclinical atherosclerosis measures from childhood to adulthood.

Shohreh F Farzan, Rima Habre, Phoebe Danza, Frederick Lurmann, W James Gauderman, Edward Avol, Theresa Bastain, Howard N Hodis, Carrie Breton

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Environmental health : a global access science source, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

  1. A Review of the Increasing Impact and Effects of Air Pollution Throughout Life and Before Birth.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Childhood Air Pollution Exposure Associated with Self-reported Bronchitic Symptoms in Adulthood.American journal of respiratory and critical care medicine · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Shohreh F FarzanDepartment of Preventive Medicine, Keck School of Medicine of University of Southern California, 2001 N. Soto Street, Los Angeles, CA, 90089, USA. sffarzan@usc.edu.ORCID 0000-0001-9897-3692
Rima HabreDepartment of Preventive Medicine, Keck School of Medicine of University of Southern California, 2001 N. Soto Street, Los Angeles, CA, 90089, USA.
Phoebe DanzaDepartment of Preventive Medicine, Keck School of Medicine of University of Southern California, 2001 N. Soto Street, Los Angeles, CA, 90089, USA.
Frederick LurmannSonoma Technology Inc., Petaluma, CA, USA.
W James GaudermanDepartment of Preventive Medicine, Keck School of Medicine of University of Southern California, 2001 N. Soto Street, Los Angeles, CA, 90089, USA.
Edward AvolDepartment of Preventive Medicine, Keck School of Medicine of University of Southern California, 2001 N. Soto Street, Los Angeles, CA, 90089, USA.
Theresa BastainDepartment of Preventive Medicine, Keck School of Medicine of University of Southern California, 2001 N. Soto Street, Los Angeles, CA, 90089, USA.
Howard N HodisDepartment of Preventive Medicine, Keck School of Medicine of University of Southern California, 2001 N. Soto Street, Los Angeles, CA, 90089, USA.
Carrie BretonDepartment of Preventive Medicine, Keck School of Medicine of University of Southern California, 2001 N. Soto Street, Los Angeles, CA, 90089, USA.
University of Southern California · USSonoma Technology (United States) · US

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Southern California Clinical and Translational Science InstituteUL1TR000130 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2012 to 2015
$36.0M
Lifecourse Approach to Developmental Repercussions of Environmental Agents on Metabolic and Respiratory Health (LA DREAMERs)UH3OD023287 · OD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BASTAIN, THERESA M, BRETON, CARRIE VAN DOREN · 2018 to 2022
$28.4M
Air pollutant exposure and progression of subclinical atherosclerosis during the critical transition from childhood to adulthoodR01ES031590 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FARZAN, SHOHREH F · 2021 to 2025
$2.9M
Preclinical Indicators & Biomarkers of Cardiovascular Effects of Arsenic ExposureR00ES024144 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FARZAN, SHOHREH F · 2016 to 2018
$746k
NCATS NIH HHS UL1 TR000130NCATS NIH HHS UL1 TR001855NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R00 ES024144NIEHS NIH HHS R01 ES031590NIEHS NIH HHS R01ES031590NIH HHS UH3 OD023287
6 · The paper itself

Abstract

backgroundChronic exposure to air pollutants is associated with increased risk of cardiovascular disease (CVD) among adults. However, little is known about how air pollution may affect the development of subclinical atherosclerosis in younger populations. Carotid artery intima-media thickness (CIMT) is a measure of subclinical atherosclerosis that provides insight into early CVD pathogenesis.

methodsIn a pilot study of 70 participants from the Southern California Children's Health Study, we investigated CIMT progression from childhood to adulthood. Using carotid artery ultrasound images obtained at age 10 and follow-up images at age 21-22, we examined associations between childhood ambient and traffic-related air pollutants with changes in CIMT over time and attained adult CIMT using linear mixed-effects models adjusted for potential confounders. Average residential childhood exposures (i.e., birth to time of measurement at 10-11 years) were assigned for regional, ambient pollutants (ozone, nitrogen dioxide, particulate matter, interpolated from regulatory air monitoring data) and traffic-related nitrogen oxides (NO

resultsFor each 1 standard deviation (SD) increase in childhood traffic-related total NO

conclusionsOverall, we observed adverse changes in CIMT over time in relation to childhood traffic-related NO

Indexed as

AdultAir PollutantsAir PollutionAtherosclerosisCarotid ArteriesCarotid Intima-Media ThicknessChildEnvironmental ExposureFemaleHumansMaleNitrogen DioxideOzoneParticulate MatterPilot ProjectsTraffic-Related PollutionAir PollutantsNitrogen DioxideOzoneParticulate MatterVehicle EmissionsAir pollutionAtherosclerosisCarotid intima media thicknessChildhoodTraffic

Identifiers

PMID33853624
PMCPMC8048028
OpenAlexW3154353066

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.