Trial reportJournal of neuroengineering and rehabilitation2021
Feasibility and preliminary efficacy of a combined virtual reality, robotics and electrical stimulation intervention in upper extremity stroke rehabilitation.
Trial report in Journal of neuroengineering and rehabilitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03903770 (Personalized Upper Extremity Rehabilitation for Persons With Moderate and Severe Impairments Due to Stroke), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Personalized Upper Extremity Rehabilitation for Persons With Moderate and Severe Impairments Due to Stroke
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- On the correlation between training modalities and recovery stages in poststroke robotic rehabilitation of the upper limb: a systematic review.Journal of neuroengineering and rehabilitation · 2026Pooled it
- Robot-assisted therapy following stroke: what effects on quality of life, cognitive and psychosocial outcomes? A systematic review.Journal of rehabilitation medicine · 2026Pooled it
- Specifications and functional impact of a self-triggered grasp neuroprosthesis developed to restore prehension in hemiparetic post-stroke subjects.Biomedical engineering online · 2024Trial
- Effectiveness of virtual reality-based rehabilitation on quality of life and upper extremity functions among stroke survivors: A systematic review and meta-analysis.International journal of nursing studies advances · 2026Review
- Poststroke Neurorehabilitation Using a Soft Robotic Glove Combined With a Virtual Environment: Preliminary Study on Feasibility, Safety, Effects, and User Satisfaction.JMIR neurotechnology · 2025Article
- Optimizing shoulder elevation assist rate in exoskeletal rehabilitation based on muscular activity indices: a clinical feasibility study.BMC neurology · 2024Article
- Extended reality to assess post-stroke manual dexterity: contrasts between the classic box and block test, immersive virtual reality with controllers, with hand-tracking, and mixed-reality tests.Journal of neuroengineering and rehabilitation · 2024Article
- Therapeutic robots for post-stroke rehabilitation.Medical review (2021) · 2024Review
- Maintaining a Dynamic Brain: A Review of Empirical Findings Describing the Roles of Exercise, Learning, and Environmental Enrichment in Neuroplasticity from 2017-2023.Brain plasticity (Amsterdam, Netherlands) · 2024Review
- Research Status and Emerging Trends in Virtual Reality Rehabilitation: Bibliometric and Knowledge Graph Study.JMIR serious games · 2023Article
- Contralaterally EMG-triggered functional electrical stimulation during serious gaming for upper limb stroke rehabilitation: a feasibility study.Frontiers in neurorobotics · 2023Article
- Reversing the Ruin: Rehabilitation, Recovery, and Restoration After Stroke.Current neurology and neuroscience reports · 2022Review
- The roles of the LpSTS and DLPFC in self-prioritization: A transcranial magnetic stimulation study.Human brain mapping · 2022Article
- Using Logistic Multivariate Analysis to Explore the Effects of Nursing and Psychological Factors on Motor and Cognitive Rehabilitation in Patients with Stroke: Based on a Retrospective Case-Control Study.Computational intelligence and neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundApproximately 80% of individuals with chronic stroke present with long lasting upper extremity (UE) impairments. We designed the perSonalized UPper Extremity Rehabilitation (SUPER) intervention, which combines robotics, virtual reality activities, and neuromuscular electrical stimulation (NMES). The objectives of our study were to determine the feasibility and the preliminary efficacy of the SUPER intervention in individuals with moderate/severe stroke.
methodsStroke participants (n = 28) received a 4-week intervention (3 × per week), tailored to their functional level. The functional integrity of the corticospinal tract was assessed using the Predict Recovery Potential algorithm, involving measurements of motor evoked potentials and manual muscle testing. Those with low potential for hand recovery (shoulder group; n = 18) received a robotic-rehabilitation intervention focusing on elbow and shoulder movements only. Those with a good potential for hand recovery (hand group; n = 10) received EMG-triggered NMES, in addition to robot therapy. The primary outcomes were the Fugl-Meyer UE assessment and the ABILHAND assessment. Secondary outcomes included the Motor Activity Log and the Stroke Impact Scale.
resultsEighteen participants (64%), in either the hand or the shoulder group, showed changes in the Fugl-Meyer UE or in the ABILHAND assessment superior to the minimal clinically important difference.
conclusionsThis indicates that our personalized approach is feasible and may be beneficial in improving UE function in individuals with moderate to severe impairments due to stroke.
trial registrationClinicalTrials.gov NCT03903770. Registered 4 April 2019. Registered retrospectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.