ArticleBMC public health2021
Long-term body mass index changes in overweight and obese adults and the risk of heart failure, cardiovascular disease and mortality: a cohort study of over 260,000 adults in the UK.
Article in BMC public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- External Validation of the MicroSimulation Core Obesity Model (MS-COM) to Predict Cardiovascular Outcomes, Mortality and Type 2 Diabetes Mellitus Incidence and Assess Cost Effectiveness.PharmacoEconomics · 2026Pooled it
- Risk factors for mild cognitive impairment in type 2 diabetes: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Associations between maternal diet, family eating habits and preschool children's dietary patterns: insights from the UPBEAT trial.Nutrition journal · 2024Trial
- Multivariable Associations of Anthropometric and Psychosocial Markers with an Elevated Abdominal Volume Index Among University Students: A Sex- and Academic Program-Stratified Analysis.Healthcare (Basel, Switzerland) · 2026Article
- Concurrence of the Core Mechanistic Tenets of the American Heart Association Statement on the Cardiovascular-Kidney-Metabolic Syndrome and the Adipokine Hypothesis of Heart Failure With Preserved Ejection Fraction.Diabetes, obesity & metabolism · 2026Article
- Article
- Burden of long-term conditions and management of people with overweight and obesity: Data from the United Kingdom primary care cohort of the IMPACT-O study.Diabetes, obesity & metabolism · 2026Article
- The dominant driver paradigm of cardiometabolic care.American journal of preventive cardiology · 2026Article
- Characteristics associated with abnormal dynamic flow in patients with severe obesity undergoing PET myocardial perfusion imaging.EJNMMI reports · 2026Article
- Life-long body mass index trajectories and cardiometabolic biomarkers-the Danish diet, cancer, and health-next generations cohort.International journal of obesity (2005) · 2025Article
- Cost-Effectiveness of Tirzepatide Versus Liraglutide, Both Adjunct to Diet and Exercise, for Patients with Obesity or Overweight: A UK Perspective.Advances in therapy · 2025Article
- Prognostic implications of the high sensitivity C-reactive protein to albumin ratio for major cardiovascular adverse events in patients undergoing noncardiac surgery.Scientific reports · 2025Article
- Long-Term Obesity and Biological Aging in Young Adults.JAMA network open · 2025Article
- Epidemiology and yearly trend of obesity and overweight in primary care in Italy.Internal and emergency medicine · 2025Article
- Prevalence of complications and comorbidities associated with obesity: a health insurance claims analysis.BMC public health · 2025Article
- Development and validation of a chronic kidney disease progression model using patient-level simulations.Renal failure · 2024Article
- Factors associated with trajectories of bone marrow lesions over 4 years: data from the Osteoarthritis Initiative.Skeletal radiology · 2024Article
- Predictive Model of the Relationship between Appearance, Eating Attitudes, and Physical Activity Behavior in Young People amid COVID-19.Nutrients · 2024Article
- More Adult Women than Men at High Cardiometabolic Risk Reported Worse Lifestyles and Self-Reported Health Status in the COVID-19 Lockdown.Nutrients · 2024Article
- COVID-19-related cardiovascular disease risk due to weight gain: a nationwide cohort study.European journal of medical research · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough obesity is a well-recognised risk factor for cardiovascular disease (CVD), the impact of long-term body mass index (BMI) changes in overweight or obese adults, on the risk of heart failure, CVD and mortality has not been quantified.
methodsThis population-based cohort study used routine UK primary care electronic health data linked to secondary care and death-registry records. We identified adults who were overweight or obese, free from CVD and who had repeated BMI measures. Using group-based trajectory modelling, we examined the BMI trajectories of these individuals and then determined incidence rates of CVD, heart failure and mortality associated with the different trajectories. Cox-proportional hazards regression determined hazards ratios for incident outcomes.
results264,230 individuals (mean age 49.5 years (SD 12.7) and mean BMI 33.8 kg/m
conclusionThe majority of adults who are overweight or obese retain their degree of overweight or obesity over the long term. Individuals with stable severe obesity experience the worst heart failure, CVD and mortality outcomes. These findings highlight the high cardiovascular toll exacted by continuing failure to tackle obesity.
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