Evidence map›Paper›PMID 33853514›Full record

ArticleCancer biology & therapy2021

Exploration of p53 plus interferon-beta gene transfer for the sensitization of human colorectal cancer cell lines to cell death.

Paulo Roberto Del Valle, Samir Andrade Mendonça, Fernanda Antunes, Aline Hunger, Rodrigo E Tamura, Daniela Bertolini Zanatta, Bryan E Strauss

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer biology & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Paulo Roberto Del ValleLaboratório De Vetores Virais, Centro De Investigação Translacional Em Oncologia/LIM24, Instituto Do Câncer Do Estado De São Paulo, Faculdade De Medicina, Universidade De São Paulo, São Paulo, Brazil.
Samir Andrade MendonçaLaboratório De Vetores Virais, Centro De Investigação Translacional Em Oncologia/LIM24, Instituto Do Câncer Do Estado De São Paulo, Faculdade De Medicina, Universidade De São Paulo, São Paulo, Brazil.
Fernanda AntunesLaboratório De Vetores Virais, Centro De Investigação Translacional Em Oncologia/LIM24, Instituto Do Câncer Do Estado De São Paulo, Faculdade De Medicina, Universidade De São Paulo, São Paulo, Brazil.
Aline HungerLaboratório De Vetores Virais, Centro De Investigação Translacional Em Oncologia/LIM24, Instituto Do Câncer Do Estado De São Paulo, Faculdade De Medicina, Universidade De São Paulo, São Paulo, Brazil.
Rodrigo E TamuraLaboratório De Vetores Virais, Centro De Investigação Translacional Em Oncologia/LIM24, Instituto Do Câncer Do Estado De São Paulo, Faculdade De Medicina, Universidade De São Paulo, São Paulo, Brazil.
Daniela Bertolini ZanattaLaboratório De Vetores Virais, Centro De Investigação Translacional Em Oncologia/LIM24, Instituto Do Câncer Do Estado De São Paulo, Faculdade De Medicina, Universidade De São Paulo, São Paulo, Brazil.
Bryan E StraussLaboratório De Vetores Virais, Centro De Investigação Translacional Em Oncologia/LIM24, Instituto Do Câncer Do Estado De São Paulo, Faculdade De Medicina, Universidade De São Paulo, São Paulo, Brazil.ORCID 0000-0002-4113-9450
Instituto do Câncer do Estado de São Paulo · BRWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While treatments for colorectal cancer continue to improve, some 50% of patients succumb within 5 years, pointing to the need for additional therapeutic options. We have developed a modified non-replicating adenoviral vector for gene transfer, called AdRGD-PG, which offers improved levels of transduction and transgene expression. Here, we employ the p53-responsive PG promoter to drive expression of p53 or human interferon-β (hIFNβ) in human colorectal cancer cell lines HCT116

Indexed as

Colorectal NeoplasmsInterferon-betaTumor Suppressor Protein p53ApoptosisCell DeathGene Transfer TechniquesHCT116 CellsHumansInterferon-betaTP53 protein, humanTumor Suppressor Protein p53Adenovirusapoptosischemotherapygene therapyimmunogenic cell death

Identifiers

PMID33853514
PMCPMC8183510
OpenAlexW3154845246

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.