Evidence map›Paper›PMID 33853493›Full record

ArticleInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group2021

Validation of a coupled electromagnetic and thermal model for estimating temperatures during magnetic nanoparticle hyperthermia.

Sri Kamal Kandala, Anirudh Sharma, Sahar Mirpour, Eleni Liapi, Robert Ivkov, Anilchandra Attaluri

Abstract read
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In one paragraph

Article in International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Advances in magnetic induction hyperthermia.Frontiers in bioengineering and biotechnology · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sri Kamal KandalaDepartment of Mechanical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.
Anirudh SharmaDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sahar MirpourDepartment of Radiology and Radiological Sciences, Johns Hopkins Hospital, Baltimore, MD, USA.
Eleni LiapiDepartment of Radiology and Radiological Sciences, Johns Hopkins Hospital, Baltimore, MD, USA.
Robert IvkovDepartment of Mechanical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.
Anilchandra AttaluriDepartment of Mechanical Engineering, The Pennsylvania State University - Harrisburg, Middletown, PA, USA.

Funding

Tumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI LENNON, ANNE MARIE · 1993 to 2022
$54.6M
Translational Application of Magnetic Hyperthermia Therapy with Adjuvant Therapies for GlioblastomaR01CA247290 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HADJIPANAYIS, CONSTANTINOS GEORGE, IVKOV, ROBERT · 2020 to 2024
$3.5M
Enhancing Liver Cancer Treatment With Image-Guided Magnetic HyperthermiaR01CA194574 · NCI · JOHNS HOPKINS UNIVERSITY · PI IVKOV, ROBERT · 2015 to 2019
$3.2M
NCI NIH HHS P50 CA062924NCI NIH HHS R01 CA194574NCI NIH HHS R01 CA247290
6 · The paper itself

Abstract

purposeAlternating magnetic field (AMF) tissue interaction models are generally not validated. Our aim was to develop and validate a coupled electromagnetic and thermal model for estimating temperatures in large organs during magnetic nanoparticle hyperthermia (MNH). MATERIALS AND

methodsCoupled finite element electromagnetic and thermal model validation was performed by comparing the results to experimental data obtained from temperatures measured in homogeneous agar gel phantoms exposed to an AMF at fixed frequency (155 ± 10 kHz). The validated model was applied to a three-dimensional (3D) rabbit liver built from computed tomography (CT) images to investigate the contribution of nanoparticle heating and nonspecific eddy current heating as a function of AMF amplitude.

resultsComputed temperatures from the model were in excellent agreement with temperatures calculated using the analytical method (error < 1%) and temperatures measured in phantoms (maximum absolute error <2% at each probe location). The 3D rabbit liver model for a fixed concentration of 5 mg Fe/cm

conclusionA validated coupled electromagnetic and thermal model was developed to estimate temperatures due to eddy current heating in homogeneous tissue phantoms. The validated model was successfully used to analyze temperature distribution in complex rabbit liver tumor geometry during MNH. In future, model validation should be extended to heterogeneous tissue phantoms, and include heat sink effects from major blood vessels.

Indexed as

Hyperthermia, InducedMagnetite NanoparticlesAnimalsElectromagnetic PhenomenaHyperthermiaRabbitsTemperatureMagnetite Nanoparticlesbioheat transfereddy currentselectromagnetic modelinggel phantomHyperthermiamagnetic nanoparticlesverification and validation

Identifiers

PMID33853493
PMCPMC8363028

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.