ArticleJournal of investigative medicine high impact case reports
Subacute Thyroiditis and Heart Failure in a Patient Presenting With COVID-19.
Article in Journal of investigative medicine high impact case reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Subacute thyroiditis as a post-COVID-19 complication: a systematic review.BMC infectious diseases · 2025Pooled it
- Subacute thyroiditis following COVID-19: A systematic review.Frontiers in endocrinology · 2023Pooled it
- COVID-19-Associated Subacute Thyroiditis: Evidence-Based Data From a Systematic Review.Frontiers in endocrinology · 2021Pooled it
- Thyroid dysfunction in COVID-19.Nature reviews. Endocrinology · 2024Review
- Subacute Thyroiditis in Active COVID-19 Infection: A Report of Two Cases With a Systematic Review of the Literature.Cureus · 2024Article
- Subacute Thyroiditis after COVID-19: A Literature Review.The American journal of tropical medicine and hygiene · 2022Review
- Pathogenic Connections in Post-COVID Conditions: What Do We Know in the Large Unknown? A Narrative Review.Viruses · 2022Review
- Thyroid Function During and After COVID-19 Infection: A Review.TouchREVIEWS in endocrinology · 2022Review
- The New Entity of Subacute Thyroiditis amid the COVID-19 Pandemic: From Infection to Vaccine.Diagnostics (Basel, Switzerland) · 2022Review
- SARS-COV-2-related immune-inflammatory thyroid disorders: facts and perspectives.Expert review of clinical immunology · 2021Review
- SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases.Journal of inflammation research · 2021Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 67-year-old male was admitted with shortness of breath and diarrhea. His COVID-19 polymerase chain reaction test was positive, and he was found to be in acute heart failure. Troponin levels were elevated, echocardiogram showed ejection fraction of 24%, and his electrocardiogram was normal. Inflammatory markers were elevated. Further testing revealed suppressed thyroid-stimulating hormone and elevated free thyroxine (T4). Differential diagnosis at this point included possible myocarditis from the viral illness, exacerbation of heart failure from the viral infection or from thyrotoxicosis was considered. Patient's heart failure improved with initiation of heart failure therapies; however, biochemically, his thyroid function tests (TFTs) did not improve, despite empiric methimazole. Thyroid antibody tests were unremarkable. Thyroid ultrasound showed mildly enlarged thyroid gland with no increased vascularity and 5-mm bilateral cysts. Thyroid dysfunction was attributed to subacute thyroiditis from COVID-19, methimazole was tapered, and prednisone was initiated. The patient's TFTs improved. With the ongoing COVID-19 pandemic, it is imperative that clinicians keep a broad differential in individuals presenting with heart failure, and obtaining baseline TFTs may be reasonable. Rapid treatment of the underlying thyroiditis is important in these patients to improve the cardiovascular outcomes. In our experience, steroid therapy showed a rapid improvement in the TFTs.
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Registered trials
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