Evidence map›Paper›PMID 33853405›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021

[

Xuefeng Yan, Sanjay Telu, Rachel M Dick, Jeih-San Liow, Paolo Zanotti-Fregonara, Cheryl L Morse, Lester S Manly, Robert L Gladding, Stal Shrestha, Walter Lerchner and 7 more

Open access · greenAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Chemogenetic Disruption of Monkey Perirhinal Neurons Projecting to the Rostromedial Caudate Impairs Associative Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  5. An Honest Reckoning With the Amygdala and Mental Illness.The American journal of psychiatry · 2024
    Review
  6. What can neuroimaging of neuromodulation reveal about the basis of circuit therapies for psychiatry?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  7. Article
  8. Evaluation of [Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  9. Article
  10. Imaging-based chemogenetics for dissecting neural circuits in nonhuman primates.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2024
    Review
  11. PET reporter systems for the brain.Trends in neurosciences · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Applications of chemogenetics in non-human primates.Current opinion in pharmacology · 2022
    Review
  18. Chronic Behavioral Manipulation via Orally Delivered Chemogenetic Actuator in Macaques.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  19. Chemogenetics as a neuromodulatory approach to treating neuropsychiatric diseases and disorders.Molecular therapy : the journal of the American Society of Gene Therapy · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 2 countries.

Xuefeng YanMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Sanjay TeluMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Rachel M DickMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-4495-8811
Jeih-San LiowMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Paolo Zanotti-FregonaraMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Cheryl L MorseMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Lester S ManlyMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Robert L GladdingMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Stal ShresthaMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Walter LerchnerLaboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Yuji NagaiDepartment of Functional Brain Imaging, National institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Takafumi MinamimotoDepartment of Functional Brain Imaging, National institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.ORCID 0000-0003-4305-0174
Sami S ZoghbiMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Robert B InnisMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Victor W PikeMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Barry J RichmondLaboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-8234-1540
Mark Ag EldridgeLaboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-4292-6832
National Institutes of Health · USNational Institutes for Quantum Science and Technology · JP

Funding

PET Radiopharmaceutical SciencesZIAMH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2009 to 2025
$69.8M
Translational Evaluation Of PET RadiotracersZIAMH002795 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2009 to 2025
$32.0M
Predoctoral Training of NeuroscientistsT32NS105604 · NINDS · UNIVERSITY OF MINNESOTA · PI A DAVID REDISH · 2018 to 2026
$3.5M
Using Computation to Achieve Breakthroughs in NeuroscienceT32MH115886 · NIMH · UNIVERSITY OF MINNESOTA · PI REDISH, A DAVID · 2018 to 2022
$1.7M
Intramural NIH HHS ZIA MH002793Intramural NIH HHS ZIA MH002795NIMH NIH HHS T32 MH115886NINDS NIH HHS T32 NS105604
6 · The paper itself

Abstract

Previous work found that [

Indexed as

AnimalsCholinergic AgentsClozapineMacaca mulattaMalePiperazinesPositron-Emission TomographyRadioligand AssayTransfectionCholinergic AgentsClozapineDREADD agonist compound 21PiperazinesClozapinecompartmental modelingdeschloroclozapineDesigner Receptors Exclusively Activated by Designer Drugspositron emission tomography

Identifiers

PMID33853405
PMCPMC8504956
OpenAlexW3154278942

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.