Evidence map›Paper›PMID 33853355›Full record

ArticleCirculation research2021

An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts.

Liuliu Yang, Yuling Han, Fabrice Jaffré, Benjamin E Nilsson-Payant, Yaron Bram, Pengfei Wang, Jiajun Zhu, Tuo Zhang, David Redmond, Sean Houghton and 14 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 3 institutions in 2 countries.

Liuliu Yang *Department of Surgery (L.Y., Y. Han, F.J., J.Z., T.E., S.C.), Weill Cornell Medicine, New York, NY.
Yuling Han *Department of Surgery (L.Y., Y. Han, F.J., J.Z., T.E., S.C.), Weill Cornell Medicine, New York, NY.
Fabrice Jaffré *Department of Surgery (L.Y., Y. Han, F.J., J.Z., T.E., S.C.), Weill Cornell Medicine, New York, NY.
Benjamin E Nilsson-Payant *Department of Microbiology (B.E.N.-P., S.U., J.K.L., B.R.t.), Icahn School of Medicine at Mount Sinai, New York, NY.
Yaron Bram *Division of Gastroenterology and Hepatology, Department of Medicine (Y.B., C.R., V.C., R.E.S.), Weill Cornell Medicine, New York, NY.
Pengfei WangAaron Diamond AIDS Research Center, Columbia University Irving Medical Center, New York, NY (P.W., Y. Huang, D.D.H.).
Jiajun ZhuDepartment of Surgery (L.Y., Y. Han, F.J., J.Z., T.E., S.C.), Weill Cornell Medicine, New York, NY.
Tuo ZhangGenomics Resources Core Facility (T.Z., J.X.), Weill Cornell Medicine, New York, NY.
David RedmondDivision of Regenerative Medicine, Ansary Stem Cell Institute (D.R., S.H.), Weill Cornell Medicine, New York, NY.
Sean HoughtonDivision of Regenerative Medicine, Ansary Stem Cell Institute (D.R., S.H.), Weill Cornell Medicine, New York, NY.
Skyler UhlDepartment of Microbiology (B.E.N.-P., S.U., J.K.L., B.R.t.), Icahn School of Medicine at Mount Sinai, New York, NY.
Alain BorczukDepartment of Pathology and Laboratory Medicine (A.B.), Weill Cornell Medicine, New York, NY.
Yaoxing HuangAaron Diamond AIDS Research Center, Columbia University Irving Medical Center, New York, NY (P.W., Y. Huang, D.D.H.).
Chanel RichardsonDivision of Gastroenterology and Hepatology, Department of Medicine (Y.B., C.R., V.C., R.E.S.), Weill Cornell Medicine, New York, NY.
Vasuretha ChandarDivision of Gastroenterology and Hepatology, Department of Medicine (Y.B., C.R., V.C., R.E.S.), Weill Cornell Medicine, New York, NY.
Joshua A AcklinGraduate School of Biomedical Sciences (J.A.A.), Icahn School of Medicine at Mount Sinai, New York, NY.
Jean K LimDepartment of Microbiology (B.E.N.-P., S.U., J.K.L., B.R.t.), Icahn School of Medicine at Mount Sinai, New York, NY.
Zhengming ChenDepartment of Population Health Sciences (Z.C.), Weill Cornell Medicine, New York, NY.
Jenny XiangGenomics Resources Core Facility (T.Z., J.X.), Weill Cornell Medicine, New York, NY.
David D HoAaron Diamond AIDS Research Center, Columbia University Irving Medical Center, New York, NY (P.W., Y. Huang, D.D.H.).
Benjamin R tenOeverDepartment of Microbiology (B.E.N.-P., S.U., J.K.L., B.R.t.), Icahn School of Medicine at Mount Sinai, New York, NY.
Robert E SchwartzDivision of Gastroenterology and Hepatology, Department of Medicine (Y.B., C.R., V.C., R.E.S.), Weill Cornell Medicine, New York, NY.
Todd EvansDepartment of Surgery (L.Y., Y. Han, F.J., J.Z., T.E., S.C.), Weill Cornell Medicine, New York, NY.
Shuibing ChenDepartment of Surgery (L.Y., Y. Han, F.J., J.Z., T.E., S.C.), Weill Cornell Medicine, New York, NY.
Cornell University · USIcahn School of Medicine at Mount Sinai · USAaron Diamond AIDS Research Center · US

Funding

Genetic Viral and Host Adaptations to Breach Species Barriers of HCVR01AI107301 · NIAID · PRINCETON UNIVERSITY · PI Thomas Pietschmann, Alexander Ploss · 2013 to 2026
$6.0M
A Gata456 Pipeline of DiscoveryR35HL135778 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI EVANS, TODD R · 2017 to 2023
$5.7M
Determining the Intrinsic and Environmental Signal Contributing to Early T1D ProgressionU01DK127777 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, SHUIBING, PARKER, STEPHEN CJ · 2020 to 2023
$3.0M
Optimization of the engineered 3D hepatic microenvironment enhances pluripotent stem cell derived hepatocyteR01DK121072 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI SCHWARTZ, ROBERT E · 2020 to 2024
$2.6M
Metallothionein 1E as a Central Regulator of Human Pancreatic Beta Cell Function and SurvivalR01DK119667 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, SHUIBING · 2019 to 2022
$2.5M
Discovery of T1DM Associated Functional Variants in Human Pancreatic Beta Cell Development and SurvivalDP3DK111907 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, SHUIBING · 2016 to 2016
$2.0M
Modeling Hepatoblastoma using pluripotent stem cell derived hepatocyte-like cellsR01CA234614 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SCHWARTZ, ROBERT E · 2019 to 2023
$1.9M
A High Content Chemical Screen to Identify the Drug Candidates Promoting Human Beta Cell ProliferationR01DK124463 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, SHUIBING · 2020 to 2023
$1.7M
A High Throughput Screening to Identify Compounds Rescuing Human Pancreatic Beta Cell Function in Diabetic ConditionsR01DK116075 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, SHUIBING · 2018 to 2020
$1.3M
Human Parainfluenza Virus 3 Infection in a Novel Human Lung Tissue ModelR21AI149033 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEE, BENHUR, LIM, JEAN KYOU · 2020 to 2021
$463k
Identification of Hepatitis B Virus permissiveness factorsR03DK117252 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI SCHWARTZ, ROBERT E · 2018 to 2019
$254k
Elucidating Virus:Host Interactions of Human Parainfluenza Virus 3 in a Novel Human Lung Tissue Explant ModelF31HL149295 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ACKLIN, JOSHUA · 2020 to 2022
$109k
NCI NIH HHS R01 CA234614NHLBI NIH HHS F31 HL149295NHLBI NIH HHS R35 HL135778NIAID NIH HHS R01 AI107301NIAID NIH HHS R21 AI149033NIDDK NIH HHS DP3 DK111907NIDDK NIH HHS R01 DK116075NIDDK NIH HHS R01 DK119667NIDDK NIH HHS R01 DK121072NIDDK NIH HHS R01 DK124463NIDDK NIH HHS R03 DK117252NIDDK NIH HHS U01 DK127777
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

AdultAgedAged, 80 and overCoculture TechniquesCOVID-19FemaleHumansImmunity, CellularInflammation MediatorsMacrophagesMaleMiddle AgedMyocardiumMyocytes, CardiacPluripotent Stem CellsSequence Analysis, RNAInflammation Mediatorsautopsydrug evaluation, preclinicalinflammationmyocytes, cardiacpyrimidines

Identifiers

PMID33853355
PMCPMC8225586
OpenAlexW3154606922

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.