Evidence map›Paper›PMID 33852994›Full record

ArticleJournal of psychiatric research2021

Chemokine MCP1 is associated with cognitive flexibility in schizophrenia: A preliminary analysis.

Federica Klaus, Kyle Mitchell, Sharon C Liou, Lisa T Eyler, Tanya T Nguyen

Abstract read
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In one paragraph

Article in Journal of psychiatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Review
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  11. The role of the immune system in postpartum psychosis.Brain, behavior, & immunity - health · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Federica KlausDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA; VA San Diego Healthcare System, Mental Illness Research, Education, and Clinical Center (MIRECC), La Jolla, CA, USA.
Kyle MitchellDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA; VA San Diego Healthcare System, Mental Illness Research, Education, and Clinical Center (MIRECC), La Jolla, CA, USA.
Sharon C LiouDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Lisa T EylerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA; VA San Diego Healthcare System, Mental Illness Research, Education, and Clinical Center (MIRECC), La Jolla, CA, USA.
Tanya T NguyenDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA; VA San Diego Healthcare System, Mental Illness Research, Education, and Clinical Center (MIRECC), La Jolla, CA, USA; Sam and Rose Stein Institute for Research on Aging, University of California San Diego, La Jolla, CA, USA. Electronic address: ttn050@health.ucsd.edu.

Funding

Characterizing the gut microbiome in schizophrenia: Relationship to age, cognition, & disease-related factorsK23MH118435 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NGUYEN, TANYA T · 2019 to 2020
$375k
NIMH NIH HHS K23 MH118435
6 · The paper itself

Abstract

backgroundPeripheral levels of pro-inflammatory biomarkers have been shown to be altered in schizophrenia (SZ) and associated with cognitive impairments, but their relevance to specific cognitive domains remains unclear.

methodsPlasma levels of cytokines, chemokines, and vascular biomarkers were quantified and compared between SZ and healthy comparison (HC) groups. Cognition was assessed using the Delis-Kaplan Executive Function System Trail Making (TM) and Color Word Interference (CWI) tests. Linear regression analyses examined differential relationships of inflammatory biomarkers with executive function between groups.

resultsPlasma levels of TNFα, ICAM1, and MCP1 were higher in individuals with SZ compared to HCs. Higher level of MCP1 was associated with increased CWI Inhibition Switching Errors in SZ but not HCs.

conclusionLike other studies, we found evidence for increased peripheral inflammation in SZ. We also showed that SZ with particularly high MCP1 levels had poor cognitive flexibility. Interventions to reduce chemokine elevations might prove beneficial for cognitive performance.

Indexed as

Cognition DisordersSchizophreniaChemokine CCL2CognitionExecutive FunctionHumansNeuropsychological TestsCCL2 protein, humanChemokine CCL2CognitionCytokinesExecutive functionPeripheral inflammationPsychosisSerious mental illness

Identifiers

PMID33852994
PMCPMC8192469

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.