ArticleCell metabolism2021
A methionine-Mettl3-N
Open access · bronzeAbstract read
In one paragraph
Article in Cell metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 90 citations in OpenAlex.
- Modeling Complex Developmental Disease: The Case of Polycystic Kidney Disease.Journal of developmental biology · 2026Review
- A Ciliary Phosphoinositide Pathway Regulates the Dosage of Polycystins in Primary Cilia.Journal of the American Society of Nephrology : JASN · 2026Article
- m6A deficiency induces dopaminergic neurodegeneration and progressive parkinsonism through a pathogenic loop with mitochondria.The Journal of clinical investigation · 2026Article
- Evolving Understanding of RNA Biology in Kidney Disease.Journal of the American Society of Nephrology : JASN · 2026Article
- Epitranscriptomics in kidney disease: insights and therapeutic potential.Kidney research and clinical practice · 2026Article
- A microscopy-based CRISPR screening platform enables organellar functional genomics and illuminates ciliary biology.Developmental cell · 2026Article
- Mettl3-Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Untangling amino acid metabolism in renal diseases: mechanisms, dysregulation, and critical gaps.Clinical kidney journal · 2026Review
- Intermittent fasting inhibits Tp53-driven glioma through gut microbiota-mediated methionine-mNature communications · 2026Article
- Chromatin remodeling and epigenetic regulation in chronic kidney disease.Frontiers in genetics · 2026Review
- Dietary methionine deprivation enhances renal resilience against ischemia-reperfusion injury in mice through modulation of glucose oxidation.Communications biology · 2025Article
- METTL3 drives malignant progression in TP53-mutant prostate cancer.Molecular biology reports · 2025Article
- MR Promotes Ferroptosis in Gastric Cancer by Regulating FANCD2 Expression Mediated by m6A Modification.Applied biochemistry and biotechnology · 2025Article
- mRNA (New York, N.Y.) · 2025Article
- Wheat-Based Protein Slows Disease Progression in Pkd1 Knockout Mice.Function (Oxford, England) · 2025Article
- Decoding mJournal of translational medicine · 2025Review
- Physiologic mechanisms underlying polycystic kidney disease.Physiological reviews · 2025Review
- Metabolic reprogramming in polycystic kidney disease and other renal ciliopathies.EMBO molecular medicine · 2025Review
- An RNA transmethylation pathway governs kidney nephrogenic potential.Nature communications · 2025Article
- The Impact of METTL3 on MDM2 Promotes Podocytes Injury During Diabetic Kidney Disease.Journal of cellular and molecular medicine · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
15 authors at 5 institutions in 1 country.
Harini RamalingamDepartment of Internal Medicine and Division of Nephrology, UT Southwestern Medical Center Dallas, TX 75390, USA.
Sonu KashyapDepartment of Anesthesiology and Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.
Patricia Cobo-StarkDepartment of Internal Medicine and Division of Nephrology, UT Southwestern Medical Center Dallas, TX 75390, USA.
Andrea FlatenDepartment of Internal Medicine and Division of Nephrology, UT Southwestern Medical Center Dallas, TX 75390, USA.
Chun-Mien ChangDepartment of Internal Medicine and Division of Nephrology, UT Southwestern Medical Center Dallas, TX 75390, USA.
Sachin HajarnisDepartment of Internal Medicine and Division of Nephrology, UT Southwestern Medical Center Dallas, TX 75390, USA.
Kyaw Zaw HeinDepartment of Anesthesiology and Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.
Jorgo LikaDepartment of Anesthesiology and Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.
Gina M WarnerDepartment of Anesthesiology and Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.
Jair M Espindola-NettoDepartment of Anesthesiology and Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.
Ashwani KumarEugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Mohammed KanchwalaEugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Chao XingEugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Eduardo N ChiniDepartment of Anesthesiology and Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: chini.eduardo@mayo.edu.
Vishal PatelDepartment of Internal Medicine and Division of Nephrology, UT Southwestern Medical Center Dallas, TX 75390, USA. Electronic address: vishald.patel@utsouthwestern.edu.
Southwestern Medical CenterSouthwestern Medical Center · USWinnMed · USMayo Clinic · USThe University of Texas Southwestern Medical Center · US
Funding
UT Southwestern O'Brien Kidney Research Core CenterP30DK079328 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI MOE, ORSON W · 2007 to 2021
$16.9MPolycystin Function Resource Development CoreU54DK126126 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI DARREN P. WALLACE · 2020 to 2026
$5.8MThe impact of RNA chemical modifications on polycystic kidney disease progressionR01DK102572 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI PATEL, VISHAL · 2015 to 2024
$3.5MNIDDK NIH HHS P30 DK079328NIDDK NIH HHS R01 DK102572NIDDK NIH HHS U54 DK126126
Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenic disorder marked by numerous progressively enlarging kidney cysts. Mettl3, a methyltransferase that catalyzes the abundant N
Indexed as
AdenosineAnimalsFemaleHumansMaleMethionineMethyltransferasesMiceMice, Inbred C57BLPolycystic Kidney DiseasesAdenosineMethionineMethyltransferasesMETTL3 protein, humanMettl3 protein, mouseN-methyladenosineAVPR2c-Mycm6A mRNA methylationmethionineMETTL3mRNA translationN(6)-methyladenosinepolycystic kidney diseaseS-adenosylmethionine
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.